DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and Hes3

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_073178.1	Gene:	Hes3 / 64628	RGDID:	621339	Length:	175	Species:	Rattus norvegicus

Alignment Length:	214	Identity:	58/214 - (27%)
Similarity:	82/214 - (38%)	Gaps:	70/214 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LERKRRARINKCLDELKDLMVATLESEGEHVTR---LEKADILELTVTHLQKMKQQRQHKRASGD 84
            :|:|||||||..|::|:.|    ||....|..|   |||||||||:|.:::.::...|      .
  Rat     1 MEKKRRARINLSLEQLRSL----LERHYSHQIRKRKLEKADILELSVKYVRSLQNSLQ------G 55

  Fly    85 ESLTPA-----EGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEKE----- 139
            ..|.|:     .|||.|              |||.:            |||   :|.|.:
  Rat    56 LWLVPSGVDYPSGFRGG--------------LPGSS------------QRL---RPGEDDSGLRC 91

  Fly   140 --VLPVTAPLSVHIANRDAYSV--PISPISSYAGSPNSNTSS-------------TSHSLLTTID 187
              :|...|..:...||....||  |..|.....|.|...:.|             :|..:|....
  Rat    92 PLLLQRRAGSTTDSANPQTASVLSPCLPAIWAPGPPAGGSQSPQSPFPPLGGLLESSTGILAPPP 156

  Fly   188 VTKME-DDSEDEENVWRPW 205
            .:..: ::......|||||
  Rat   157 ASNCQAENPRPGFRVWRPW 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	25/56 (45%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	10/43 (23%)
Hes3	NP_073178.1	bHLH-O_HES3	1..55	CDD:381503	26/63 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..175		8/50 (16%)
		WRPW motif	172..175		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840