DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and HES4

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_001135939.1	Gene:	HES4 / 57801	HGNCID:	24149	Length:	247	Species:	Homo sapiens

Alignment Length:	191	Identity:	56/191 - (29%)
Similarity:	91/191 - (47%)	Gaps:	15/191 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKRASGD 84
            ||::|::||||||:.|.:||.|::..|..|....::||||||||:||.||:.:::.:.....|.|
Human    65 KPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAALSAD 129

  Fly    85 ESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEK-----EVLPVT 144
            .::...  :|:|:...:.||:|.|:...|:...:.::|:.||...|.|:.|:.:     ...|..
Human   130 PAVLGK--YRAGFHECLAEVNRFLAGCEGVPADVRSRLLGHLAACLRQLGPSRRPASLSPAAPAE 192

  Fly   145 APLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDSEDEENVWRPW 205
            ||.....|.|        |:....|.|....:......||...........:.....||||
Human   193 APAPEVYAGR--------PLLPSLGGPFPLLAPPLLPGLTRALPAAPRAGPQGPGGPWRPW 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	27/56 (48%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	12/43 (28%)
HES4	NP_001135939.1	HLH	62..119	CDD:238036	27/53 (51%)
HES4	NP_001135939.1	Hairy_orange	136..174	CDD:284859	10/37 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140959
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840