DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and hey1

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_001007911.1	Gene:	hey1 / 493293	XenbaseID:	XB-GENE-486694	Length:	300	Species:	Xenopus tropicalis

Alignment Length:	177	Identity:	55/177 - (31%)
Similarity:	89/177 - (50%)	Gaps:	29/177 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKR 80
            ||..:.::|::||.|||..|.||:.|:.:..|.:|.  .:||||:||::||.||:.:       .
Frog    49 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKML-------H 104

  Fly    81 ASGDESLTPAEG----FRS-GYIHAVNEVSRSLSQLPGMNVS--LGTQLMTHLGQRLNQIQPAEK 138
            .:|.:....|..    :|| |:...:.||:|.||.:.||:.:  |..:|::||....:|.:.|.
Frog   105 TAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGMDTTDPLRVRLVSHLNNYASQREAAN- 168

  Fly   139 EVLPVTAPLSV-HI------ANRDAYSVPISPISSYAGSPNSNTSST 178
                 ||...: ||      |:....|.|:....:...|.||.:|||
Frog   169 -----TAHTGIGHIPWGGTFAHHPHLSHPLLLAQTAHTSANSTSSST 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	24/60 (40%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	15/50 (30%)
hey1	NP_001007911.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH_SF	40..121	CDD:381792	26/80 (33%)
		ORANGE	119..165	CDD:128787	15/45 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..232		6/12 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..300
		YRPW motif	290..293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910