DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and usp10

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_001006761.1	Gene:	usp10 / 448441	XenbaseID:	XB-GENE-966184	Length:	805	Species:	Xenopus tropicalis

Alignment Length:	247	Identity:	49/247 - (19%)
Similarity:	86/247 - (34%)	Gaps:	79/247 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLQMSEMSKTYQYRKVMKPMLERKRRARINKCLDELK------DLMVATLESEGE--HVTRLE 57
            ::|.|::|  |..:.::...|:.|.....:|.:.|:|:|      .|....|.::|.  ::....
Frog   375 VTSPQVTE--KQVEIKEGPVPVSEDPVAIKIAELLEEVKLVHKPVSLQPRGLINKGNWCYINATL 437

  Fly    58 KADILELTVTHLQK-----MKQQR-------------------------QHKRASGDE---SLTP 89
            :|.:....:.||.|     .|.||                         :.|:|||::   .:.|
Frog   438 QALVACPPMYHLMKSIPVYTKAQRPCTSTPMIDSFVRLMNEFTNMPILPKAKQASGEKVIRDIRP 502

  Fly    90 AEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLN----QIQPAEKEVLPVTAPLSVH 150
            ...|...||:.:..|.:|.....|..    .....:||..||    ::...:|.:||...  .:|
Frog   503 GAPFEPAYIYRLLTVFKSSLSEKGRQ----EDAEEYLGFILNGLHEEMLSLKKLLLPQND--KIH 561

  Fly   151 IANRDAYSVPISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDSEDEENVW 202
            |.|..      .|:|...                  ::.|.|.:..|||  |
Frog   562 INNGP------DPVSEKE------------------EINKDEQEGSDEE--W 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	16/99 (16%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	10/47 (21%)
usp10	NP_001006761.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..170
		UCH	422..799	CDD:306860	38/198 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..593		11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165161042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930