DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and E(spl)m7-HLH

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_536753.1	Gene:	E(spl)m7-HLH / 43160	FlyBaseID:	FBgn0002633	Length:	186	Species:	Drosophila melanogaster

Alignment Length:	206	Identity:	96/206 - (46%)
Similarity:	130/206 - (63%)	Gaps:	33/206 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EMSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKM 72
            ||||||||||||||:||||||||||||||||||||...:...|:  .:.|||||||:||.||:|:
  Fly     6 EMSKTYQYRKVMKPLLERKRRARINKCLDELKDLMAECVAQTGD--AKFEKADILEVTVQHLRKL 68

  Fly    73 KQQRQHKRASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAE 137
            |:.::|..|:      |.:.||:|||.|.|||||:|:.||.::|:.||.||||||.||||::.
  Fly    69 KESKKHVPAN------PEQSFRAGYIRAANEVSRALASLPRVDVAFGTTLMTHLGMRLNQLEQ-- 125

  Fly   138 KEVLPVTAPLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDSEDEE--- 199
                |:..|.:|:           :|:|...||.:|:::.:|.|..::|........|::|.
  Fly   126 ----PMEQPQAVN-----------TPLSIVCGSSSSSSTYSSASSCSSISPVSSGYASDNESLLQ 175

  Fly   200 -----NVWRPW 205
                 .|||||
  Fly   176 ISSPGQVWRPW 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	41/61 (67%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	27/43 (63%)
E(spl)m7-HLH	NP_536753.1	HLH	13..73	CDD:238036	41/61 (67%)
E(spl)m7-HLH	NP_536753.1	ORANGE	81..125	CDD:128787	27/43 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469356
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5073
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1483774at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1011
	9	8.900