DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and HELT

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_001287710.1	Gene:	HELT / 391723	HGNCID:	33783	Length:	242	Species:	Homo sapiens

Alignment Length:	111	Identity:	36/111 - (32%)
Similarity:	54/111 - (48%)	Gaps:	14/111 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MSEMSKTYQYRKVMKPMLERKRRARINKCLDELKDL--MVATLESEGEHVTRLEKADILELTVTH 68
            ||:..|..:...|...::|::||.|||:||:||...  |....:|.|    :||||:|||:||.:
Human     1 MSDKLKERKRTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQSSG----KLEKAEILEMTVQY 61

  Fly    69 LQKMKQQRQHKRASGDESLTP-AEGFRSGY-------IHAVNEVSR 106
            |:.:......:.....|.|.. |..|..||       :|.:..|.|
Human    62 LRALHSADFPRGREKAELLAEFANYFHYGYHECMKNLVHYLTTVER 107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	24/63 (38%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	6/23 (26%)
HELT	NP_001287710.1	bHLH-O_HELT	14..69	CDD:381414	23/58 (40%)
		Hairy_orange	87..127	CDD:400076	6/21 (29%)
		PRK14951	<133..>207	CDD:237865
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740