Protein Alignment E(spl)mgamma-HLH and HES3

DIOPT Version :9

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 205
• Identity: 62/205 - (30%)
• Similarity: 83/205 - (40%)
• Gaps: 49/205 - (23%)

  Fly    23 LERKRRARINKCLDELKDLMVATLESEGEHVTR---LEKADILELTVTHLQKMKQQ--------R 76
            :|:|||||||..|::||.|    ||....|..|   |||||||||:|.:::.::..        |
Human     1 MEKKRRARINVSLEQLKSL----LEKHYSHQIRKRKLEKADILELSVKYMRSLQNSLQGLWPVPR 61

  Fly    77 QHKRASGDESLTP--AEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPA-EK 138
            ..::.||..|..|  ::..|.|     :||...| :.|.:..|.....|...|  |.|..|| .:
Human    62 GAEQPSGFRSCLPGVSQLLRRG-----DEVGSGL-RCPLVPESAAGSTMDSAG--LGQEAPALFR 118

  Fly   139 EVLP-VTAPLSVHIANRD-------AYSVPISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDS 195
            ...| |.||.......|.       ..|:|.|..|.....|.|:..:.|..|
Human   119 PCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCAESPGL------------- 170

  Fly   196 EDEENVWRPW 205
              ...|||||
Human   171 --GLRVWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	26/64 (41%)
		ORANGE	91..135	CDD:128787	11/43 (26%)
HES3	NP_001019769.1	HLH	1..54	CDD:238036	26/56 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		14/66 (21%)
		WRPW motif	175..178		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840