Protein Alignment E(spl)mgamma-HLH and HES5

DIOPT Version :9

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: XP_005244808.1
• Gene: HES5 / 388585
• HGNCID: 19764
• Length: 198
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 55/232 - (23%)
• Similarity: 89/232 - (38%)
• Gaps: 76/232 - (32%)

  Fly     8 EMSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESE-GEHV--TRLEKADILELTVTHL 69
            |:....:..::.||::|:.||.|||..:::||.|    ||.| ..|.  ::||||||||:.|::|
Human     9 ELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLL----LEQEFARHQPNSKLEKADILEMAVSYL 69

  Fly    70 QKMKQQR--------QHK---------------------RASGDESLTPAEGFRSGYIHAVNEVS 105
            :..|.:|        .|:                     .|:|.:||  .:.:..||...:.|..
Human    70 KHSKGERARAPRAPSSHRAPAPPRPAARSPPPRLPAAFVAAAGPKSL--HQDYSEGYSWCLQEAV 132

  Fly   106 RSLSQLPGMNVSLGTQ--LMTHLGQRLNQIQPAEKEVLPVTAPLSVHIANRDAYSVPISPISSYA 168
            :.|:    ::.:..||  |:.|. ||     |......|...|.:...|...|.|...:..::.|
Human   133 QFLT----LHAASDTQMKLLYHF-QR-----PPAAPAAPAKEPKAPGAAPPPALSAKATAAAAAA 187

  Fly   169 GSPNSNTSSTSHSLLTTIDVTKMEDDSEDEENVWRPW 205
            ..|..                          .:||||
Human   188 HQPAC--------------------------GLWRPW 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	27/72 (38%)
		ORANGE	91..135	CDD:128787	10/45 (22%)
HES5	XP_005244808.1	HLH	14..71	CDD:238036	25/60 (42%)
		Hairy_orange	118..153	CDD:295407	8/39 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1011
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840