DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and dpn

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_476923.1	Gene:	dpn / 35800	FlyBaseID:	FBgn0010109	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	184	Identity:	59/184 - (32%)
Similarity:	100/184 - (54%)	Gaps:	21/184 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MSKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMK 73
            :||. :.||..||::|::||||||.||:|||.|::..::.:....|:||||||||:||.|||.::
  Fly    35 LSKA-ELRKTNKPIMEKRRRARINHCLNELKSLILEAMKKDPARHTKLEKADILEMTVKHLQSVQ 98

  Fly    74 QQRQHKRASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPA-- 136
            :|:.:.....|.|:  .:.|::|::....||:|.:||:.|::..:..:|..||.|..|.::..
  Fly    99 RQQLNMAIQSDPSV--VQKFKTGFVECAEEVNRYVSQMDGIDTGVRQRLSAHLNQCANSLEQIGS 161

  Fly   137 --------EKEVLPVTAPLSVHIANRDAYSVPISPISSYAGSPNSNTSSTSHSL 182
                    ...:.|.||.        .|...|:.|......:.||.|.|::.::
  Fly   162 MSNFSNGYRGGLFPATAV--------TAAPTPLFPSLPQDLNNNSRTESSAPAI 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	32/61 (52%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	13/43 (30%)
dpn	NP_476923.1	HLH	39..101	CDD:238036	31/61 (51%)
dpn	NP_476923.1	ORANGE	114..158	CDD:128787	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438350
Domainoid	1	1.000	45	1.000	Domainoid score	I4621
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840