DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and heyl

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_859425.1	Gene:	heyl / 335134	ZFINID:	ZDB-GENE-030131-7074	Length:	310	Species:	Danio rerio

Alignment Length:	187	Identity:	54/187 - (28%)
Similarity:	87/187 - (46%)	Gaps:	35/187 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQHKR 80
            ||..:.::|::||.|||..|.||:.|:.:..|.:|.  ::||||:||::||.||:.:       .
Zfish    44 RKKRRGIIEKRRRDRINHSLSELRRLVPSAFEKQGS--SKLEKAEILQMTVDHLKLL-------H 99

  Fly    81 ASGDESLTPAEG----FRS-GYIHAVNEVSRSLSQLPGMNVS--LGTQLMTHLGQRLNQIQPAEK 138
            |.|.:....|..    :|: |:...|.||.|.||.|.|:..|  :|.:|::||....:::.|..:
Zfish   100 AMGGKGYFDARALAVDYRTLGFRECVGEVVRYLSSLEGVESSDPIGARLVSHLSHCASELDPLLQ 164

  Fly   139 EVLPVTAPL---------SVHIANRDAYSVPISPISSYAGSPNSNTSSTSHSLLTTI 186
            .  |...|.         .:..|:..|.|.|.        .||:....|.|...|.:
Zfish   165 S--PAALPFPPWPWASFPQLQAASPPASSTPF--------PPNARRDLTPHGTATIL 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	24/60 (40%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	15/50 (30%)
heyl	NP_859425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		HLH	44..101	CDD:238036	24/65 (37%)
		ORANGE	115..159	CDD:128787	15/43 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..208		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740