Protein Alignment E(spl)mgamma-HLH and HES1

DIOPT Version :10

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 70/262 - (26%)
• Similarity: 115/262 - (43%)
• Gaps: 86/262 - (32%)

  Fly    14 QYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQH 78
            ::||..||::|::||||||:.|.:||.|::..|:.:....::||||||||:||.||:.:::.:..
Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    79 KRASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQI---------Q 134
            ...|.|.|:...  :|:|:...:|||:|.||...|:|..:.|:|:.||...:.||         .
Human    98 AALSTDPSVLGK--YRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPH 160

  Fly   135 PAEKEVLP-----------------------------------------------------VTAP 146
            ||.:...|                                                     |.||
Human   161 PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAP 225

  Fly   147 ---LSVHIAN-RDAYSVPISPI-SSYAGS---PNSNTSSTSHSLLTTIDVTKMEDDSEDEENVWR 203
               .:..|.| ..|:|.|:.|: :|.:|:   ||:.:.|:..||..              :::||
Human   226 DGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTA--------------DSMWR 276

  Fly   204 PW 205
            ||
Human   277 PW 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	bHLH-O_ESMB_like	9..77	CDD:381584	28/62 (45%)
		ORANGE	91..135	CDD:128787	16/52 (31%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	109..148	CDD:462193	14/40 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		3/42 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		9/39 (23%)
		WRPW motif	275..278		2/2 (100%)