Protein Alignment E(spl)mgamma-HLH and HES1

DIOPT Version :9

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_005515.1
• Gene: HES1 / 3280
• HGNCID: 5192
• Length: 280
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 70/262 - (26%)
• Similarity: 115/262 - (43%)
• Gaps: 86/262 - (32%)

  Fly    14 QYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQH 78
            ::||..||::|::||||||:.|.:||.|::..|:.:....::||||||||:||.||:.:::.:..
Human    33 EHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMT 97

  Fly    79 KRASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQI---------Q 134
            ...|.|.|:...  :|:|:...:|||:|.||...|:|..:.|:|:.||...:.||         .
Human    98 AALSTDPSVLGK--YRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQPH 160

  Fly   135 PAEKEVLP-----------------------------------------------------VTAP 146
            ||.:...|                                                     |.||
Human   161 PALQAPPPPPPGPGGPQHAPFAPPPPLVPIPGGAAPPPGGAPCKLGSQAGEAAKVFGGFQVVPAP 225

  Fly   147 ---LSVHIAN-RDAYSVPISPI-SSYAGS---PNSNTSSTSHSLLTTIDVTKMEDDSEDEENVWR 203
               .:..|.| ..|:|.|:.|: :|.:|:   ||:.:.|:..||..              :::||
Human   226 DGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGPSLTA--------------DSMWR 276

  Fly   204 PW 205
            ||
Human   277 PW 278

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	28/61 (46%)
		ORANGE	91..135	CDD:128787	16/52 (31%)
HES1	NP_005515.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		4/10 (40%)
		bHLH-O_HES1_4	33..95	CDD:381465	28/61 (46%)
		Hairy_orange	110..148	CDD:400076	14/37 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..200		3/42 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..280		9/39 (23%)
		WRPW motif	275..278		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840