Protein Alignment E(spl)mgamma-HLH and HEYL

DIOPT Version :9

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_055386.2
• Gene: HEYL / 26508
• HGNCID: 4882
• Length: 328
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 59/230 - (25%)
• Similarity: 96/230 - (41%)
• Gaps: 65/230 - (28%)

  Fly     5 QMSEM--------SKTYQYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADI 61
            |:|:|        |...|.||..:.::|::||.|||..|.||:.|:....|.:|.  ::||||::
Human    25 QLSQMARPLSTPSSSQMQARKKHRGIIEKRRRDRINSSLSELRRLVPTAFEKQGS--SKLEKAEV 87

  Fly    62 LELTVTHLQKMKQQRQHKRASGDESLTPAEG----FRS-GYIHAVNEVSRSLSQLPGMNV---SL 118
            |::||.||:.:       .|:|......|..    ||| |:...:.||.|.|..|.|.:.   .:
Human    88 LQMTVDHLKML-------HATGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSRADPV 145

  Fly   119 GTQLMTHLGQRLNQIQPAEKEVLPVTAP---------------LSVHIA-------------NRD 155
            ..:|::||.....:::|:.....|:..|               ||..:|             :..
Human   146 RIRLLSHLNSYAAEMEPSPTPTGPLAFPAWPWSFFHSCPGLPALSNQLAILGRVPSPVLPGVSSP 210

  Fly   156 AYSVP---ISPISSYAG---------SPNSNTSST 178
            ||.:|   .:|:....|         .|:...|||
Human   211 AYPIPALRTAPLRRATGIILPARRNVLPSRGASST 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	23/61 (38%)
		ORANGE	91..135	CDD:128787	13/51 (25%)
HEYL	NP_055386.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57		9/31 (29%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	42..111		27/77 (35%)
		HLH	42..100	CDD:238036	24/66 (36%)
		ORANGE	115..162	CDD:128787	13/46 (28%)
		Atrophin-1	<136..311	CDD:331285	19/110 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..308		3/7 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740