Protein Alignment E(spl)mgamma-HLH and HEY2

DIOPT Version :9

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_036391.1
• Gene: HEY2 / 23493
• HGNCID: 4881
• Length: 337
• Species: Homo sapiens
• Alignment Length: 207
• Identity: 61/207 - (29%)
• Similarity: 99/207 - (47%)
• Gaps: 41/207 - (19%)

  Fly     2 SSLQMSEMSKTYQY--RKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILEL 64
            |.::::..:.|.|.  ||..:.::|::||.|||..|.||:.|:....|.:|.  .:||||:||::
Human    33 SVIRLNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQM 95

  Fly    65 TVTHLQKMKQQRQHKRASGDESLTPAEG----FRS-GYIHAVNEVSRSLSQLPGMNVS--LGTQL 122
            ||.|| ||.|      |:|.:....|..    |.| |:...:.||:|.||.:.|::.|  |..:|
Human    96 TVDHL-KMLQ------ATGGKGYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRL 153

  Fly   123 MTHLGQRLNQIQPAEKEVLPVTAPLSVHIANRDAYSVPISP---------ISSYAGSPNS--NTS 176
            ::||.....|     :|...:|:.::.|       ..|:.|         :.:....||.  .:.
Human   154 VSHLSTCATQ-----REAAAMTSSMAHH-------HHPLHPHHWAAAFHHLPAALLQPNGLHASE 206

  Fly   177 STSHSLLTTIDV 188
            ||...|.||.:|
Human   207 STPCRLSTTSEV 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	27/63 (43%)
		ORANGE	91..135	CDD:128787	15/50 (30%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		5/18 (28%)
		bHLH-O_HEY2	40..121	CDD:381490	32/89 (36%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		30/77 (39%)
		ORANGE	119..165	CDD:128787	15/50 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	307..337
		YRPW motif	327..330

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740