DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and Bhlhe40

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_035628.1	Gene:	Bhlhe40 / 20893	MGIID:	1097714	Length:	411	Species:	Mus musculus

Alignment Length:	220	Identity:	55/220 - (25%)
Similarity:	95/220 - (43%)	Gaps:	48/220 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSLQMSEMSKTYQYRKVMK-------------PMLERKRRARINKCLDELKDLMVATLESEGEH 52
            :|.:..:.|.:.|:.|:.:|             .::|:|||.|||:|:.:||||:       .||
Mouse    25 LSGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLL-------PEH 82

  Fly    53 VT-----RLEKADILELTVTH---LQKMKQQRQHK-----------RASGDESLTPAEGFRSGYI 98
            :.     .||||.:||||:.|   |..:..|:|.|           ..||.......|.|.||:.
Mouse    83 LKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQ 147

  Fly    99 HAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEKEVLPV-TAPLSVHIANRDAYSVPIS 162
            ....||.:.|::.........:||:|||.:.::::........|: :||.:|.:..:.::....|
Mouse   148 TCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGS 212

  Fly   163 --------PISSYAGSPNSNTSSTS 179
                    |:.....:|:....|.|
Mouse   213 EGPGKNCVPVIQRTFAPSGGEQSGS 237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	27/82 (33%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	12/43 (28%)
Bhlhe40	NP_035628.1	Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer. /evidence=ECO:0000250	1..139		34/120 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	29/95 (31%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..294		5/31 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840