Protein Alignment E(spl)mgamma-HLH and Bhlhe40

DIOPT Version :10

• Sequence 1: NP_524504.2
• Gene: E(spl)mgamma-HLH / 43151
• FlyBaseID: FBgn0002735
• Length: 205
• Species: Drosophila melanogaster
• Sequence 2: NP_035628.1
• Gene: Bhlhe40 / 20893
• MGIID: 1097714
• Length: 411
• Species: Mus musculus
• Alignment Length: 220
• Identity: 55/220 - (25%)
• Similarity: 95/220 - (43%)
• Gaps: 48/220 - (21%)

  Fly     1 MSSLQMSEMSKTYQYRKVMK-------------PMLERKRRARINKCLDELKDLMVATLESEGEH 52
            :|.:..:.|.:.|:.|:.:|             .::|:|||.|||:|:.:||||:       .||
Mouse    25 LSGMDFAHMYQVYKSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLL-------PEH 82

  Fly    53 VT-----RLEKADILELTVTH---LQKMKQQRQHK-----------RASGDESLTPAEGFRSGYI 98
            :.     .||||.:||||:.|   |..:..|:|.|           ..||.......|.|.||:.
Mouse    83 LKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKIIALQSGLQAGDLSGRNLEAGQEMFCSGFQ 147

  Fly    99 HAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEKEVLPV-TAPLSVHIANRDAYSVPIS 162
            ....||.:.|::.........:||:|||.:.::::........|: :||.:|.:..:.::....|
Mouse   148 TCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSELLQGGASRKPLDSAPKAVDLKEKPSFLAKGS 212

  Fly   163 --------PISSYAGSPNSNTSSTS 179
                    |:.....:|:....|.|
Mouse   213 EGPGKNCVPVIQRTFAPSGGEQSGS 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	bHLH-O_ESMB_like	9..77	CDD:381584	29/88 (33%)
		ORANGE	91..135	CDD:128787	12/43 (28%)
Bhlhe40	NP_035628.1	Essential for interaction with BMAL1, E-box binding and repressor activity against the CLOCK-BMAL1 heterodimer. /evidence=ECO:0000250	1..139		34/120 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		bHLH-O_DEC1	40..129	CDD:381592	29/95 (31%)
		Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000250	75..79		3/3 (100%)
		ORANGE	140..184	CDD:128787	12/43 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	227..294		3/11 (27%)