DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mgamma-HLH and hes2

DIOPT Version :9

Sequence 1:	NP_524504.2	Gene:	E(spl)mgamma-HLH / 43151	FlyBaseID:	FBgn0002735	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	XP_002933889.1	Gene:	hes2 / 100038090	XenbaseID:	XB-GENE-486138	Length:	191	Species:	Xenopus tropicalis

Alignment Length:	202	Identity:	54/202 - (26%)
Similarity:	89/202 - (44%)	Gaps:	47/202 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QYRKVMKPMLERKRRARINKCLDELKDLMVATLESEGEHVTRLEKADILELTVTHLQKMKQQRQH 78
            :.||.:||::|::||||||:.|::||.|::..:..:....::||||||||:||..|:.:...
Frog    27 ELRKTLKPLMEKRRRARINESLNQLKTLILPLIGKDNSRYSKLEKADILEMTVRFLRDIPPV--- 88

  Fly    79 KRASGDESLTPAEGFRSGYIHAVNEVSRSLSQLPGMNVSLGTQLMTHLGQRLNQIQPAEKEVLPV 143
                  .:..||:.::.||...|..:|..|::...:......:|:.|| ||
Frog    89 ------PAQNPADRYKEGYRACVERLSAILNKSHVLTGEASNRLLNHL-QR-------------- 132

  Fly   144 TAPLSVHIANRDAYSVP----------ISPISSYAGSPNSNTSSTSHSLLTTIDVTKMEDDSEDE 198
                |..:...|.:..|          :||.:|...||..|..| ||        .......:..
Frog   133 ----SPELCCSDCHHPPKSHSPRIVLHVSPRTSQLESPLLNQPS-SH--------RPAPCPPQLN 184

  Fly   199 ENVWRPW 205
            .::||||
Frog   185 SSIWRPW 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mgamma-HLH	NP_524504.2	HLH	15..77	CDD:238036	26/61 (43%)
E(spl)mgamma-HLH	NP_524504.2	ORANGE	91..135	CDD:128787	10/43 (23%)
hes2	XP_002933889.1	bHLH-O_HES2	25..89	CDD:381469	26/70 (37%)
hes2	XP_002933889.1	Hairy_orange	97..133	CDD:369405	10/54 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010