DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)mdelta-HLH and BHLHE40

DIOPT Version :9

Sequence 1:NP_524503.2 Gene:E(spl)mdelta-HLH / 43150 FlyBaseID:FBgn0002734 Length:173 Species:Drosophila melanogaster
Sequence 2:NP_003661.1 Gene:BHLHE40 / 8553 HGNCID:1046 Length:412 Species:Homo sapiens


Alignment Length:166 Identity:49/166 - (29%)
Similarity:78/166 - (46%) Gaps:28/166 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 KVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKA------QQQQ 75
            |:...|:|:|||.|:|..:.:||||:.:.:..  ..:..||||.:||||:.::||      ||||
Human    54 KLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHVKALTNLIDQQQQ 116

  Fly    76 RV--------ANPQSPPPDQVNLDKFRAGYTQAAYEV-SHIFSTVPGLDLKFG---THL------ 122
            ::        |...|....:...:.|.:|:...|.|| .::.......|||..   |||      
Human   117 KIIALQSGLQAGELSGRNVETGQ
EMFCSGFQTCAREVLQYLAKHENTRDLKSSQLVTHLHRVVSE 181

  Fly   123 MKQLGHQLKDMKQEEEIIDMAEEPVNLADQKRSKSP 158
            :.|.|...|......:::|..|:|.:.|  |.|:.|
Human   182 LLQGGTSRKPSDPAPKVMDFKEKPSSPA--KGSEGP 215

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)mdelta-HLHNP_524503.2 bHLH-O_ESMB_like 9..77 CDD:381584 26/65 (40%)
ORANGE 91..135 CDD:128787 14/53 (26%)
BHLHE40NP_003661.1 Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer 1..139 28/86 (33%)
bHLH-O_DEC1 40..129 CDD:381592 27/76 (36%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558 75..79 3/3 (100%)
ORANGE 140..184 CDD:128787 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..303 10/36 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140937
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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