DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and Hes7

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_149030.2	Gene:	Hes7 / 84653	MGIID:	2135679	Length:	225	Species:	Mus musculus

Alignment Length:	172	Identity:	45/172 - (26%)
Similarity:	70/172 - (40%)	Gaps:	56/172 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRV---A 78
            |:.|||:|::||.|:|..|:||:.|:::....|..:..|||||:|||..|.||:  ::.||   .
Mouse    14 KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLR--ERSRVEPPG 76

  Fly    79 NPQSPPPDQVNLDK-FRAGYTQAAYEV------------SHIFSTVPGLDLKFGTHLMKQLGHQL 130
            .|:||..|...|.. :.:|:.:....:            |.:||.:.|
Mouse    77 VPRSPGQDAEALASCYLSGFRECLLRLAAFAHDASPAARSQLFSALHG----------------- 124

  Fly   131 KDMKQEEEIIDMAEEPVNLADQKRSKSPREEDIHHGEEVWRP 172
                                 .:|.|.||.|.:..|....||
Mouse   125 ---------------------YRRPKPPRPEAVDPGLPAPRP 145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/59 (42%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	5/56 (9%)
Hes7	NP_149030.2	HLH	14..73	CDD:238036	26/60 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..225		9/60 (15%)
		WRPW motif	221..224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830916
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740