DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and Bhlhe41

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_077789.1	Gene:	Bhlhe41 / 79362	MGIID:	1930704	Length:	410	Species:	Mus musculus

Alignment Length:	104	Identity:	37/104 - (35%)
Similarity:	57/104 - (54%)	Gaps:	13/104 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKA----- 71
            |:...|:...|:|:|||.|:|..:.:||||:.:.:..  ..:..||||.:||||:.:|||
Mouse    41 TKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKL--TTLGHLEKAVVLELTLKHLKALTALT 103

  Fly    72 -QQQQRVANPQS-----PPPDQVNLDKFRAGYTQAAYEV 104
             ||.|::...|:     ..|.|.:||.|.:|:...|.||
Mouse   104 EQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEV 142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	27/70 (39%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	6/14 (43%)
Bhlhe41	NP_077789.1	bHLH-O_DEC2	31..122	CDD:381593	28/82 (34%)
		ORANGE	129..175	CDD:128787	6/14 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..410
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830860
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840