DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and hey2

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_571697.2	Gene:	hey2 / 58146	ZFINID:	ZDB-GENE-000526-1	Length:	324	Species:	Danio rerio

Alignment Length:	157	Identity:	44/157 - (28%)
Similarity:	72/157 - (45%)	Gaps:	14/157 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..:.::|::||.|:|..|.||:.|:....:.||.  :|||||:||::||::||  ..|.....
Zfish    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLK--MLQATGGK 109

  Fly    81 QSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQEEEIIDMAEE 145
            .......:.:|....|:.:...||:...|:|.|||  ....|..:|...|.....:.|...|.
Zfish   110 GYFDAHSLAMDFLSIGFRECLTEVARYLSSVEGLD--SSDPLRVRLVSHLSSCASQREAAAMT-- 170

  Fly   146 PVNLADQKRSKSPREEDIHHGEEVWRP 172
             .::|..:::..|     ||......|
Zfish   171 -TSIAHHQQALHP-----HHWAAALHP 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/60 (42%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	12/43 (28%)
hey2	NP_571697.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		HLH	49..105	CDD:238036	24/59 (41%)
		Hairy_orange	125..162	CDD:284859	11/38 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..324
		YRPW motif	314..317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740