DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and hey1

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_997726.1	Gene:	hey1 / 58008	ZFINID:	ZDB-GENE-000607-70	Length:	317	Species:	Danio rerio

Alignment Length:	181	Identity:	44/181 - (24%)
Similarity:	76/181 - (41%)	Gaps:	45/181 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLK---AQQQQRV 77
            ||..:.::|::||.|:|..|.||:.|:....:.||.  :|||||:||::||::||   |...:..
Zfish    49 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHAAGGKGY 111

  Fly    78 ANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLD------LKFGTHL-------------- 122
            .:..:...|...|     |:.:...|.:...|.:.|||      ::..:||
Zfish   112 FDAHALAMDYRGL-----GFRECLAETARYLSIIEGLDNTDPLRIRLVSHLNSYASQREAHSGLG 171

  Fly   123 -----------MKQLGHQLKDMKQEEEIIDMAEE----PVNLADQKRSKSP 158
                       ...|.|.|...:|:::...:|..    |.:.:....|.||
Zfish   172 HLAWGSAFGTPPSHLAHHLLLQQQQQQGAPLARSTSSPPSSNSSSPSSSSP 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/63 (40%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	11/74 (15%)
hey1	NP_997726.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		3/9 (33%)
		HLH	49..106	CDD:238036	24/58 (41%)
		ORANGE	119..165	CDD:128787	10/50 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..264		6/30 (20%)
		YRPW motif	307..310
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740