Protein Alignment E(spl)mdelta-HLH and HES2

DIOPT Version :9

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_061962.2
• Gene: HES2 / 54626
• HGNCID: 16005
• Length: 173
• Species: Homo sapiens
• Alignment Length: 165
• Identity: 48/165 - (29%)
• Similarity: 77/165 - (46%)
• Gaps: 12/165 - (7%)

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..|||||::||||:|..|.:||.||:..:..:....|||||||:||:||.:|  |:....:.|
Human    14 RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFL--QELPASSWP 76

  Fly    81 QSPPPDQVNLDKFRAGYTQAAYEVSHIFSTV----PGLDLKFGTHLMKQLGHQLKDMKQEEEIID 141
            .:.|   :..|.:|.||:.....::.:....    |.:..:...||.::......|..:..:...
Human    77 TAAP---LPCDSYREGYSACVARLARVLPACRVLEPAVSARLLEHLWRRAASATLDGGRAGDSSG 138

  Fly   142 ---MAEEPVNLADQKRSKSPREEDIHHGEEVWRPW 173
               .|..|.:..:...:..|.......|..:||||
Human   139 PSAPAPAPASAPEPASAPVPSPPSPPCGPGLWRPW 173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	30/60 (50%)
		ORANGE	91..135	CDD:128787	8/47 (17%)
HES2	NP_061962.2	HLH	12..70	CDD:238036	30/57 (53%)
		ORANGE	84..127	CDD:128787	7/42 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..173		7/44 (16%)
		WRPW motif	170..173		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5317
OMA	1	1.010	-	-		QHG47782
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800