DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and hey1

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_001007911.1	Gene:	hey1 / 493293	XenbaseID:	XB-GENE-486694	Length:	300	Species:	Xenopus tropicalis

Alignment Length:	164	Identity:	40/164 - (24%)
Similarity:	68/164 - (41%)	Gaps:	39/164 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..:.::|::||.|:|..|.||:.|:....:.||.  :|||||:||::||::||  ........
Frog    49 RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLK--MLHTAGGK 109

  Fly    81 QSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLD------LKFGTHLMKQLGHQLKDMKQEEEI 139
            .......:.:|....|:.:...||:...|.:.|:|      ::..:||.
Frog   110 GYFDAHALAMDYRSLGFRECLAEVARYLSIIEGMDTTDPLRVRLVSHLN---------------- 158

  Fly   140 IDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW 173
                    |.|.|:.:.:.....|.|     .||
Frog   159 --------NYASQREAANTAHTGIGH-----IPW 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	24/60 (40%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	9/49 (18%)
hey1	NP_001007911.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH_SF	40..121	CDD:381792	24/75 (32%)
		ORANGE	119..165	CDD:128787	12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..300
		YRPW motif	290..293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910