DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and E(spl)m8-HLH

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_524513.1	Gene:	E(spl)m8-HLH / 43161	FlyBaseID:	FBgn0000591	Length:	179	Species:	Drosophila melanogaster

Alignment Length:	183	Identity:	62/183 - (33%)
Similarity:	94/183 - (51%)	Gaps:	23/183 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FMTKTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQ 72
            :.||||.|:||.||:|||:||||||..||.||.|:.:.....|  :.:::||::||..|.:::.|
  Fly     3 YTTKTQIYQKVKKPMLERQRRARMNKCLDNLKTLVAELRGDDG--ILRMDKAEMLESAVIFMRQQ 65

  Fly    73 Q-QQRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQE 136
            : .::||..:...|    ||.|:.||..|..|||.:.::.||:.:..|..:|..||...|:::|.
  Fly    66 KTPKKVAQEEQSLP----LDSFKNGYMNAVNEVSRVMASTPGMSVDLGKSVMTHLGRVYKNLQQF 126

  Fly   137 EEIIDMAEEPVNLAD----QKRSKSPREEDIHHG------------EEVWRPW 173
            .|....|:...|..|    .|...||.....|..            :.:||||
  Fly   127 HEAQSAADFIQNSMDCSSMDKAPLSPASSGYHSDCDSPAPSPQPMQQPLWRPW 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	30/68 (44%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	15/43 (35%)
E(spl)m8-HLH	NP_524513.1	HLH	10..67	CDD:238036	26/58 (45%)
E(spl)m8-HLH	NP_524513.1	ORANGE	81..125	CDD:128787	15/43 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469367
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5073
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378299at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900