DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and E(spl)m5-HLH

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_524511.1	Gene:	E(spl)m5-HLH / 43158	FlyBaseID:	FBgn0002631	Length:	178	Species:	Drosophila melanogaster

Alignment Length:	190	Identity:	64/190 - (33%)
Similarity:	102/190 - (53%)	Gaps:	29/190 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAVQGQR---FMTKTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQ-VSKLEKADI 61
            ||.|...   |::|||||.||.||||||:||||||..||.||.|:.   :.||:. :.:::||::
  Fly     1 MAPQSNNSTTFVSKTQHYLKVKKPLLERQRRARMNKCLDTLKTLVA---EFQGDDAILRMDKAEM 62

  Fly    62 LELTVNYLKAQQQQRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQL 126
            ||..:.:::.|..::.| |.||.|    :|.|:.||..|..|:|.:.:..|.:.:..|..:|..|
  Fly    63 LEAALVFMRKQVVKQQA-PVSPLP----MDSFKNGYMNAVSEISRVMACTPAMSVDVGKTVMTHL 122

  Fly   127 GHQLKDMKQEEE----IIDMAEEPVNLA---------DQKRSKSPREEDIHHGEEVWRPW 173
            |.:.:.|.|.::    :......|::.|         |.:.:.||:..:    |.:||||
  Fly   123 GVEFQRMLQADQVQTSVTTSTPRPLSPASSGYHSDNEDSQSAASPKPVE----ETMWRPW 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	31/68 (46%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	13/43 (30%)
E(spl)m5-HLH	NP_524511.1	HLH	20..72	CDD:238036	25/54 (46%)
E(spl)m5-HLH	NP_524511.1	ORANGE	87..131	CDD:128787	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469362
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5073
Isobase	1	0.950	-	0	Normalized mean entropy	S5317
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1378299at2759
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.850