DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and hes4

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_988870.1	Gene:	hes4 / 394465	XenbaseID:	XB-GENE-487830	Length:	281	Species:	Xenopus tropicalis

Alignment Length:	150	Identity:	54/150 - (36%)
Similarity:	86/150 - (57%)	Gaps:	15/150 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVAN 79
            :||.:||::|::||||:|..|.:||.||:|.:.....:.||||||||||:||.:|:  ..|||..
Frog    34 HRKSSKPIMEKRRRARINESLGQLKTLILDALKKDSSRHSKLEKADILEMTVKHLR--NLQRVQM 96

  Fly    80 PQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGH------QLKDMKQEEE 138
            ..:...|...|.|:|||:.:...||:...||..|::.:..|.|   |||      |:..|..::.
Frog    97 TAALTADPSVLGKYRAGFNECMNEVTRFLSTCEGVNTEVRTRL---LGHLSSCLGQIVAMNYQQP 158

  Fly   139 IIDMAEEPVNLADQKRSKSP 158
              ..:::|:::  |..|.:|
Frog   159 --PSSQQPLHV--QLPSSTP 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	30/61 (49%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	16/49 (33%)
hes4	NP_988870.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		4/9 (44%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	110..147	CDD:369405	13/39 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..281
		WRPW motif. /evidence=ECO:0000255	278..281
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010