DRSC/TRiP Functional Genomics Resources

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Protein Alignment E(spl)mdelta-HLH and HES3

DIOPT Version :9

Sequence 1:NP_524503.2 Gene:E(spl)mdelta-HLH / 43150 FlyBaseID:FBgn0002734 Length:173 Species:Drosophila melanogaster
Sequence 2:NP_001019769.1 Gene:HES3 / 390992 HGNCID:26226 Length:186 Species:Homo sapiens


Alignment Length:194 Identity:51/194 - (26%)
Similarity:71/194 - (36%) Gaps:59/194 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANPQSPPPDQ 87
            :|:|||||:|:.|::||.|:......|..: .||||||||||:|.|:::.|..  .....|.|  
Human     1 MEKKRRARINVSLEQLKSLLEKHYSHQIRK-RKLEKADILELSVKYMRSLQNS--LQGLWPVP-- 60

  Fly    88 VNLDKFRAGYTQAAYEVSHIFSTVPGLD--LKFGTHLMKQLGHQLKDMKQEEEIIDMA---EE-- 145
                       :.|.:.|...|.:||:.  |:.|..:...|...|.........:|.|   :|  
Human    61 -----------RGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAP 114

  Fly   146 ------------PVNLADQKRSKSPR------------------------EEDIHHGEEVWRPW 173
                        |...|...||..|.                        .|....|..|||||
Human   115 ALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCAESPGLGLRVWRPW 178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E(spl)mdelta-HLHNP_524503.2 bHLH-O_ESMB_like 9..77 CDD:381584 25/53 (47%)
ORANGE 91..135 CDD:128787 9/45 (20%)
HES3NP_001019769.1 HLH 1..54 CDD:238036 25/55 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 128..186 11/51 (22%)
WRPW motif 175..178 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140889
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10985
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.840

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