Protein Alignment E(spl)mdelta-HLH and HES3

DIOPT Version :10

• Sequence 1: NP_524503.2
• Gene: E(spl)mdelta-HLH / 43150
• FlyBaseID: FBgn0002734
• Length: 173
• Species: Drosophila melanogaster
• Sequence 2: NP_001019769.1
• Gene: HES3 / 390992
• HGNCID: 26226
• Length: 186
• Species: Homo sapiens
• Alignment Length: 194
• Identity: 51/194 - (26%)
• Similarity: 71/194 - (36%)
• Gaps: 59/194 - (30%)

  Fly    23 LERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANPQSPPPDQ 87
            :|:|||||:|:.|::||.|:......|..: .||||||||||:|.|:::.|..  .....|.|
Human     1 MEKKRRARINVSLEQLKSLLEKHYSHQIRK-RKLEKADILELSVKYMRSLQNS--LQGLWPVP-- 60

  Fly    88 VNLDKFRAGYTQAAYEVSHIFSTVPGLD--LKFGTHLMKQLGHQLKDMKQEEEIIDMA---EE-- 145
                       :.|.:.|...|.:||:.  |:.|..:...|...|.........:|.|   :|
Human    61 -----------RGAEQPSGFRSCLPGVSQLLRRGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAP 114

  Fly   146 ------------PVNLADQKRSKSPR------------------------EEDIHHGEEVWRPW 173
                        |...|...||..|.                        .|....|..|||||
Human   115 ALFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPPQPASSRCAESPGLGLRVWRPW 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/53 (47%)
		ORANGE	91..135	CDD:128787	9/45 (20%)
HES3	NP_001019769.1	bHLH-O_HES3	1..55	CDD:381503	25/56 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..186		11/51 (22%)
		WRPW motif	175..178		2/2 (100%)