DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E(spl)mdelta-HLH and Hes1

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_077336.3	Gene:	Hes1 / 29577	RGDID:	62081	Length:	281	Species:	Rattus norvegicus

Alignment Length:	126	Identity:	51/126 - (40%)
Similarity:	77/126 - (61%)	Gaps:	6/126 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TKTQHYRKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQ 74
            |.::| ||.:||::|::||||:|..|.:||.||:|.:.....:.||||||||||:||.:|:..|:
  Rat    30 TASEH-RKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQR 93

  Fly    75 QRVANPQSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQLGHQLKDMKQ 135
            .::....|..|..  |.|:|||:::...||:...||..|::.:..|.|   |||....|.|
  Rat    94 AQMTAALSTDPSV--LGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRL---LGHLANCMTQ 149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	32/66 (48%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	15/43 (35%)
Hes1	NP_077336.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		6/14 (43%)
		bHLH-O_HES1_4	33..95	CDD:381465	31/62 (50%)
		Hairy_orange	110..148	CDD:400076	13/40 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..281
		WRPW motif	276..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334584
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840