DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and HEY2

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	NP_036391.1	Gene:	HEY2 / 23493	HGNCID:	4881	Length:	337	Species:	Homo sapiens

Alignment Length:	113	Identity:	36/113 - (31%)
Similarity:	60/113 - (53%)	Gaps:	10/113 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..:.::|::||.|:|..|.||:.|:....:.||.  :|||||:||::||::||  ..|.....
Human    49 RKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGS--AKLEKAEILQMTVDHLK--MLQATGGK 109

  Fly    81 QSPPPDQVNLDKFRAGYTQAAYEVSHIFSTVPGLD------LKFGTHL 122
            .......:.:|....|:.:...||:...|:|.|||      ::..:||
Human   110 GYFDAHALAMDFMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHL 157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	25/60 (42%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	11/38 (29%)
HEY2	NP_036391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		2/2 (100%)
		bHLH-O_HEY2	40..121	CDD:381490	25/75 (33%)
		Transcriptional repression and interaction with NCOR1 and SIN3A. /evidence=ECO:0000250	47..116		25/70 (36%)
		ORANGE	119..165	CDD:128787	11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..337
		YRPW motif	327..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140905
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740