DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E(spl)mdelta-HLH and hes2

DIOPT Version :9

Sequence 1:	NP_524503.2	Gene:	E(spl)mdelta-HLH / 43150	FlyBaseID:	FBgn0002734	Length:	173	Species:	Drosophila melanogaster
Sequence 2:	XP_002933889.1	Gene:	hes2 / 100038090	XenbaseID:	XB-GENE-486138	Length:	191	Species:	Xenopus tropicalis

Alignment Length:	175	Identity:	52/175 - (29%)
Similarity:	75/175 - (42%)	Gaps:	29/175 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RKVTKPLLERKRRARMNLYLDELKDLIVDTMDAQGEQVSKLEKADILELTVNYLKAQQQQRVANP 80
            ||..|||:|::||||:|..|::||.||:..:.....:.||||||||||:||.:|:
Frog    29 RKTLKPLMEKRRRARINESLNQLKTLILPLIGKDNSRYSKLEKADILEMTVRFLR---------- 83

  Fly    81 QSPP-PDQVNLDKFRAGYTQAAYEVSHIFSTVPGLDLKFGTHLMKQL----------------GH 128
            ..|| |.|...|:::.||......:|.|.:....|..:....|:..|                .|
Frog    84 DIPPVPAQNPADRYKEGYRACVERLSAILNKSHVLTGEASNRLLNHLQRSPELCCSDCHHPPKSH 148

  Fly   129 QLKDMKQEEEIIDMAEEPVNLADQKRSKSPREEDIHHGEEVWRPW 173
            ..:.:..........|.|  |.:|..|..|..........:||||
Frog   149 SPRIVLHVSPRTSQLESP--LLNQPSSHRPAPCPPQLNSSIWRPW 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E(spl)mdelta-HLH	NP_524503.2	bHLH-O_ESMB_like	9..77	CDD:381584	29/60 (48%)
E(spl)mdelta-HLH	NP_524503.2	ORANGE	91..135	CDD:128787	9/59 (15%)
hes2	XP_002933889.1	bHLH-O_HES2	25..89	CDD:381469	31/69 (45%)
hes2	XP_002933889.1	Hairy_orange	97..133	CDD:369405	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47782
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000785
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020