DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nf1 and IRA2

DIOPT Version :9

Sequence 1:NP_733132.2 Gene:Nf1 / 43149 FlyBaseID:FBgn0015269 Length:2802 Species:Drosophila melanogaster
Sequence 2:NP_014560.1 Gene:IRA2 / 854073 SGDID:S000005441 Length:3079 Species:Saccharomyces cerevisiae


Alignment Length:2771 Identity:558/2771 - (20%)
Similarity:1031/2771 - (37%) Gaps:635/2771 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   250 DFVEYFKTENKKSKTL----------VWPLQMLLLILNPSCLEAV--VNELQQS------EKEKE 296
            |:.|:|.:..:....|          |.|...:|..|....:..:  .|||..:      :....
Yeast   559 DYDEHFLSVTRLDNVLELYTHFDDTEVLPHTSVLKFLTTLTMFDIDLFNELNATSFKYIPDCTMH 623

  Fly   297 KDKEKVAS--KSAQSTSRDKDFSAKQFIESIKRGLGQHSPSKQVTESAAIACVKLCKASTYINNT 359
            :.||:.:|  .:|..|..:|....|...:.:|:.....|.:|:.        ||..|  ..:.|.
Yeast   624 RPKERTSSFNNTAHETGSEKTSGIKHITQGLKKLTSLPSSTKKT--------VKFVK--MLLRNL 678

  Fly   360 DSNNVVF---------KLVQFFI---------NDLKALLFNPAK--------PFSRGQGYN---- 394
            :.|..|.         .|:.||.         .:|.::||  ||        ..|.||.:|    
Yeast   679 NGNQAVSDVALLDTMRALLSFFTMTSAVFLVDRNLPSVLF--AKRLIPIMGTNLSVGQDWNSKIN 741

  Fly   395 -------------FADIELM-------IDCWVSCFRIN----PHNIEALKVCLNLSSPQAYHFVI 435
                         |..::|:       .|..:...|::    .:|:...|:||.....:.:..:.
Yeast   742 NSLMVCLKKNSTTFVQLQLIFFSSAIQFDHELLLARLSIDTMANNLNMQKLCLYTEGFRIFFDIP 806

  Fly   436 VCSLLRLAHIYVDFRLQNKNPFRIVNQPRLSWWPQ-----TDVV----------------HYRSA 479
            ....||.| |.|......|..|.|:....|..:|.     ||:|                |::.:
Yeast   807 SKKELRKA-IAVKISKFFKTLFSIIADILLQEFPYFDEQITDIVASILDGTIINEYGTKKHFKGS 870

  Fly   480 ELRALFTDTLNKATQGYIAHTP---------------LRYITSLTLKSKDTQKGLTRAEEGPAHK 529
            ......|......:....:.||               |..:.|.|.::.|....|..:.:..:..
Yeast   871 SPSLCSTTRSRSGSTSQSSMTPVSPLGLDTDICPMNTLSLVGSSTSRNSDNVNSLNSSPKNLSSD 935

  Fly   530 MLLLLLV--RLIHA-----------DPTLLLNTQG-KVAHEVQSSTLELINGL-VSLVHQTTMPD 579
            ..|..||  |..||           .||.|.:..| :.:..||....|.|:.. :::.:.|.:..
Yeast   936 PYLSHLVAPRARHALGGPSSIIRNKIPTTLTSPPGTEKSSPVQRPQTESISATPMAITNSTPLSS 1000

  Fly   580 VAQEAMEALLALHAP-EKIEV--WNPEAPINTFWDVSSQVLFSISQKLIQHQIANYTDVLKWLRE 641
            .|       ..:.:| :||..  ::.|: :..|...::..   |.:.||...:...|  |:..|.
Yeast  1001 AA-------FGIRSPLQKIRTRRYSDES-LGKFMKSTNNY---IQEHLIPKDLNEAT--LQDARR 1052

  Fly   642 ILICRNTFLQRHKDY----AHVGSQIAICKQAHIKMEVVFFMYLWSVDLDAVLTSLSCFGLLCEE 702
            |:|...:..:|...|    .::.|.:....|....:....|:.:.|.|:|...|:.|....|...
Yeast  1053 IMINIFSIFKRPNSYFIIPHNINSNLQWVSQDFRNIMKPIFVAIVSPDVDLQNTAQSFMDTLLSN 1117

  Fly   703 AEICCSSDELTVGFIMPNYHIYQELAQLSTSATDSRICFFD----NTHGNVLSRLTLQ-KRIMTL 762
            ......|||   ...:..||:.     .|.:.|...:..||    |....:|..:|:: .::.:.
Yeast  1118 VITYGESDE---NISIEGYHLL-----CSYTVTLFAMGLFDLKINNEKRQILLDITVKFMKVRSH 1174

  Fly   763 LRKIEHCVHGVQPAWEETFRNWEVSSKVLQTYPKCKGEDGQAEVFHRGMGKRRASHQSSEHDLEE 827
            |..|....|.::          .:|.....|:|...|..|:| :|        .|..||:..:|:
Yeast  1175 LAGIAEASHHME----------YISDSEKLTFPLIMGTVGRA-LF--------VSLYSSQQKIEK 1220

  Fly   828 QIN-----------------EWANMTW-----FLLALGGVCLHKRSSSRQMLLQ-QSQNNASLGS 869
            .:.                 :.|:.||     |:.|:   |....::|..:..| :::||....:
Yeast  1221 TLKIAYTEYLSAINFHERNIDDADKTWVHNIEFVEAM---CHDNYTTSGSIAFQRRTRNNILRFA 1282

  Fly   870 LAQNSLYSSSTSSGHGSLHPSTVSLSTLPPAPPQDVSYCPVTQFVGQLLRL--LVCSNEKI---- 928
            ...|::...|....:...|..|.|.| |......|     ...|.|.|..|  ::..|:||    
Yeast  1283 TIPNAILLDSMRMIYKKWHTYTHSKS-LEKQERND-----FRNFAGILASLSGILFINKKILQEM 1341

  Fly   929 -------GLNIQKNVKELVGEE------------------MSTQLYP----ILFDQVRAIVEKFF 964
                   ...::||:...:.::                  :|.:|:|    :||:.:|..:::. 
Yeast  1342 YPYLLDTVSELKKNIDSFISKQCQWLNYPDLLTRENSRDILSVELHPLSFNLLFNNLRLKLKEL- 1405

  Fly   965 DQQGQVNVNVTDINTQFIEHTIYIMKSILDPKANKDPNNDQPSPSEHLGVTSIEGMMLGIVRYVR 1029
             ....:::...:.:...:|..|.::::||    .:|.:|              ..|||.....|.
Yeast  1406 -ACSDLSIPENESSYVLLEQIIKMLRTIL----GRDDDN--------------YVMMLFSTEIVD 1451

  Fly  1030 HLDMTVYAIRIKTKLC-----------QLVEVMMKRRDDLAFRQEMKFRNKLVEYLTDWVMGTSH 1083
            .:|:....|:.....|           ::...:.....:|..:.....:||.:..:|||     .
Yeast  1452 LIDLLTDEIKKIPAYCPKYLKAIIQMTKMFSALQHSEVNLGVKNHFHVKNKWLRQITDW-----F 1511

  Fly  1084 QIAPPSSAD----AAILTNTSLIFRDLDQACME-------AVAALLRG--LPLQPEESDRGDLMD 1135
            |::.....|    :..|....|:.||:|...::       |:|.|.|.  |.:.|..|| .:|..
Yeast  1512 QVSIAREYDFENLSKPLKEMDLVKRDMDILYIDTAIEASTAIAYLTRHTFLEIPPAASD-PELSR 1575

  Fly  1136 AKSALFLKYFTLFMNLLNDCIDSSEAEKEMNNTPLLPPRPRMAAGKLTALRNATILAMSNLLGAN 1200
            ::|.:|..||.:.|..|       |...:.:|.|:      ....|::.|.:..||:::||...|
Yeast  1576 SRSVIFGFYFNILMKGL-------EKSSDRDNYPV------FLRHKMSVLNDNVILSLTNLSNTN 1627

  Fly  1201 IDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQQGTEFDT------LAETVLADRFEQLVQLVTMI 1259
            :|:.|..::.:||:.:...|.||:||...|:   |.:.|      |.:...||:|.:.......:
Yeast  1628 VDASLQFTLPMGYSGNRNIRNAFLEVFINIV---TNYRTYTAKTDLGKLEAADKFLRYTIEHPQL 1689

  Fly  1260 SDKGELPIAMALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVSDCMQTLFRGNSL 1324
            |..|        |.|...|.:|..|..|:..|:.::....::..:...|:|.|.....:.|.||.
Yeast  1690 SSFG--------AAVCPASDIDAYAAGLINAFETRNATHIVVAQLIKNEIEKSSRPTDILRRNSC 1746

  Fly  1325 GSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTE-DIEQHRNNLIALTQKV 1388
            .::.::...:..|..||...|:||::.::...:  .||::  :|.|.: |.|:.....:....::
Yeast  1747 ATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRD--FFEIE--KLKPEDSDAERQIELFVKYMNEL 1807

  Fly  1389 FDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIGAVGTVIFLRFINPAIVSPQELGIVDK 1453
            .::|.||...|||.|..:|..:|:|..::||:   :.|.|.|:.:||||..||:|||....|:|.
Yeast  1808 LESISNSVSYFPPPLFYICQNIYKVACEKFPD---HAIIAAGSFVFLRFFCPALVSPDSENIIDI 1869

  Fly  1454 QVHSSAKRGLMLMSKILQNIANHVE-FSKEQHMLCFNDFLRDHFEAGRRFFIQIASDCETVDQTS 1517
            . |.|.||..:.::|::|||||..| ||:...:....|||:   |...|.|..:|..|.| |:|.
Yeast  1870 S-HLSEKRTFISLAKVIQNIANGSENFSRWPALCSQKDFLK---ECSDRIFRFLAELCRT-DRTI 1929

  Fly  1518 HSMSFISDANVLA-----LHRLLWTHQEKI-GDYLSSSR-DHKAVGRRPFDKMATL-----LAYL 1570
             .:...:|...:|     ||..::.:..:: .:.|:.:: |...:....|.|...|     |..|
Yeast  1930 -DIQVRTDPTPIAFDYQFLHSFVYLYGLEVRRNVLNEAKHDDGDIDGDDFYKTTFLLIDDVLGQL 1993

  Fly  1571 GPPEHKPVDSHMMFSS----YARWSSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSK 1631
            |.|:       |.||:    |.|....|     :.|:......|.....:|..:.:......||.
Yeast  1994 GQPK-------MEFSNEIPIYIREHMDD-----YPELYEFMNRHAFRNIETSTAYSPSVHESTSS 2046

  Fly  1632 SGYPVFYYIARRYKIGETNGD------LLIYHVILTLKPFCHSPFEVVIDFTHTCSDNRFRTEFL 1690
            .|.|:.......:.....:.|      |.||..|.|.| .|     ::||.|..........:|:
Yeast  2047 EGIPIITLTMSNFSDRHVDIDTVAYKFLQIYARIWTTK-HC-----LIIDCTEFDEGGLDMRKFI 2105

  Fly  1691 QKWFYVLPTVAYENVHAVYIYNCN-SWVREYTKFHDRILAPLKGNRKLLFLESPNKLTDFIDAEQ 1754
            .....:||.||.:|....|.:|.| :::..|.|..|:....:.......|:.|.:      |...
Yeast  2106 SLVMGLLPEVAPKNCIGCYYFNVNETFMDNYGKCLDKDNVYVSSKIPHYFINSNS------DEGL 2164

  Fly  1755 QKLPGAT---LSLDEDLKVFSNALKL----SHKDTKVAIKVGPTALQI--TSAEKTKV----LAH 1806
            .|..|.|   |.:.:|::|..:.:.|    .::.|.|::|:|....|:  .:..:.|:    ...
Yeast  2165 MKSVGITGQGLKVLQDIRVSLHDITLYDEKRNRFTPVSLKIGDIYFQVLHETPRQYKIRDMGTLF 2229

  Fly  1807 SVLLNDVYYASEIEEVCLVDDN----QFTLSITNESGQLSFIHNDCDNIVQ----AIIHIRNRWE 1863
            .|..||||..|.|.||.:....    :||::..:|. :|.|.......||:    |.|.:.:.:|
Yeast  2230 DVKFNDVYEISRIFEVHVSSITGVAAEFTVTFQDER-RLIFSSPKYLEIVKMFYYAQIRLESEYE 2293

  Fly  1864 L------SQPDS--VTVHQKIRPKDVPGTLLNMALLNLGSCDPNLRTAAYNLLCALTATFDLKIE 1920
            :      |.|:|  ....||.|.|.:...|| ::|:.|......::.::|||:.|..|:|.|...
Yeast  2294 MDNNSSTSSPNSNNKDKQQKERTKLLCHLLL-VSLIGLFDESKKMKNSSYNLIAATEASFGLNFG 2357

  Fly  1921 GQLLETQGLCIPSNNTIFIKSVSEKLATNEPHLT-------LEFLEESIQGFQRSTIELKHLCLE 1978
            .....:..:.:|.:.|.|:..:.:.||.:.|.||       ||.|:.::         :.|:.:.
Yeast  2358 SHFHRSPEVYVPEDTTTFLGVIGKSLAESNPELTAYMFIYVLEALKNNV---------IPHVYIP 2413

  Fly  1979 Y----MTPWLKNLVKFCKSNDDSK-KLKVSQILDKLINLTIDQKEMYPSVQAKIWGSIGQIPELI 2038
            :    ::.|:.||.:.....||.: ...:|.|...||.|::.:.:........:|..:.....|.
Yeast  2414 HTICGLSYWIPNLYQHVYLADDEEGPENISHIFRILIRLSVRETDFKAVYMQYVWLLLLDDGRLT 2478

  Fly  2039 DMVLDNFLHKSI-----------TYGLGSPQVEIMADTAVALASANVQLVSKKVITRICRVMDKS 2092
            |:::|..::.::           |..|    :.::..|.||      ..:.:|::.:|...:   
Yeast  2479 DIIVDEVINHALERDSENRDWKKTISL----LTVLPTTEVA------NNIIQKILAKIRSFL--- 2530

  Fly  2093 CTNPTQYLE-QHMMWDDIAILGRYLLMLSFNNCLDVATSVPYLFHTITFLVCSGSLSMRASTHGL 2156
               |:..|| ....|.::.||.:..:.:.|...|.|...:|.:...::.|:..|...:|:|.|.|
Yeast  2531 ---PSLKLEAMTQSWSELTILVKISIHVFFETSLLVQMYLPEILFIVSLLIDVGPRELRSSLHQL 2592

  Fly  2157 VINIIHSLCTCTNPSFSEEAQRVLRLSLDEFSLPKFYLLFGISKVKSAAVTAFRSSCRHPTDKWL 2221
            ::|:.|||  ..|.:..::.:..|....|.|:..|...:||.|:.|.                  
Yeast  2593 LMNVCHSL--AINSALPQDHRNNLDEISDIFAHQKVKFMFGFSEDKG------------------ 2637

  Fly  2222 GNERVTQPLPADRERLSLPSLEVITDALLEIMEACMRDVPDCEWLNTWTSLARSF----AFCYNP 2282
               |:.|...|.........|:...:.:|.:||     .......|.|.:..:.:    .|..|.
Yeast  2638 ---RILQIFSASSFASKFNILDFFINNILLLME-----YSSTYEANVWKTRYKKYVLESVFTSNS 2694

  Fly  2283 ALQPRALIVYGCISKS-VTDHEVKQLL----RILVKALESFNDLILIEALVMCLTRIQPLLRPES 2342
            .|..|::::.|.:.|| :|:...|.:|    :::.:...:...|.|..:.:...::|...|.|..
Yeast  2695 FLSARSIMIVGIMGKSYITEGLCKAMLIETMKVIAEPKITDEHLFLAISHIFTYSKIVEGLDPNL 2759

  Fly  2343 PIHRALFWVAISVLQLDEITLYGAGLALLEQNLHTLKSQGCFDKKET-IAEVMMKTREKLEWHFK 2406
            .:.:.|||.:...|:.....::...|..:...:..|......::.|| :...::|.|:.......
Yeast  2760 DLMKHLFWFSTLFLESRHPIIFEGALLFVSNCIRRLYMAQFENESETSLISTLLKGRKFAHTFLS 2824

  Fly  2407 QLDHAVGLSF-RSNFHFALVGHLIKGFRHPTPTT------------------VSRTSRVLTMLLG 2452
            ::::..|:.: ..||...|:..:.||..:|...:                  :::.|......:.
Yeast  2825 KIENLSGIVWNEDNFTHILIFIINKGLSNPFIKSTAFDFLKMMFRNSYFEHQINQKSDHYLCYMF 2889

  Fly  2453 IIAKPLHRDKFEVTPDSVAYLTALVAVSEEVRSRCHVKHALPR----WPADLSSSVENGEASGGV 2513
            ::...|:.::||.....|.:...:|.:..        |:.:|:    |   |||..||...    
Yeast  2890 LLYFVLNCNQFEELLGDVDFEGEMVNIEN--------KNTIPKILLEW---LSSDNENANI---- 2939

  Fly  2514 QAIGLPLSRRQKSWDILDQSALQFARQHKVPTLQNARVLFKTQRSFSVPTTKDPNNATGIEERQE 2578
                                           ||....:|||                        
Yeast  2940 -------------------------------TLYQGAILFK------------------------ 2949

  Fly  2579 RGSRSSVSNESNVLLDPEVLPDLSIQALVLTVLAT------LVKYSSDEGETRVLYQYLAEGSVV 2637
                .||::|          |.....||::..|.|      |..||....|.|.:..: .:.|..
Yeast  2950 ----CSVTDE----------PSRFRFALIIRHLLTKKPICALRFYSVIRNEIRKISAF-EQNSDC 2999

  Fly  2638 FPKVFPVIHSLLDQKINNILSVSHDQVVLNSVQNIIQNMLA 2678
            .|..|.:::.|:....:|.|...|::    |::.:.:..|:
Yeast  3000 VPLAFDILNLLVTHSESNSLEKLHEE----SIERLTKRGLS 3036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nf1NP_733132.2 RasGAP_Neurofibromin 1242..1575 CDD:213332 93/346 (27%)
CRAL_TRIO_2 1633..1767 CDD:404584 32/143 (22%)
PH_NF1 1759..1868 CDD:270123 32/135 (24%)
MOR2-PAG1_mid <1931..>2109 CDD:372971 37/201 (18%)
IRA2NP_014560.1 RasGAP_Neurofibromin_like 1672..1990 CDD:213341 89/338 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 106 1.000 Domainoid score I1446
eggNOG 1 0.900 - - E1_KOG1826
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005399
OrthoInspector 1 1.000 - - otm46912
orthoMCL 1 0.900 - - OOG6_103500
Panther 1 1.100 - - O PTHR10194
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.810

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