Protein Alignment Nf1 and RASA2

DIOPT Version :9

• Sequence 1: NP_733132.2
• Gene: Nf1 / 43149
• FlyBaseID: FBgn0015269
• Length: 2802
• Species: Drosophila melanogaster
• Sequence 2: XP_016862457.1
• Gene: RASA2 / 5922
• HGNCID: 9872
• Length: 872
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 125/605 - (20%)
• Similarity: 223/605 - (36%)
• Gaps: 179/605 - (29%)

  Fly  1214 NPDLQ---TRAAFMEVLTQILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGEL-PIAMALANV 1274
            :||:|   ..||:  :|::|.:              |:.:.::.||.::....:| |.|.|:|
Human   358 SPDVQPISASAAY--ILSEICR--------------DKNDAVLPLVRLLLHHDKLVPFATAVA-- 404

  Fly  1275 VTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVSDCM--QTLFRGNSLGSKIMAFCFKIYG 1337
                                             |:::.|..  .|:||||||.::.:....||.|
Human   405 ---------------------------------ELDLKDTQDANTIFRGNSLATRCLDEMMKIVG 436

  Fly  1338 ASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIEQHRNNLIALTQKVFDAIINSSDRFPPQ 1402
            ..||::.|:|::..:.| ..::| |:||.:|...:::|.::.||.....|:|:.|:.||...|..
Human   437 GHYLKVTLKPILDEICD-SSKSC-EIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTV 499

  Fly  1403 LRSMCHCLYQVLSKRFPNLLQNNIGAVGTVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMS 1467
            :..:.:.|.|:.::||||.......||.:.:||||...|:|||....:......:...|.|.|:|
Human   500 MCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLIS 564

  Fly  1468 KILQNIANHVEFSK-----EQHMLC--FNDFLRDHFEAGRRFFIQIASDCETVDQTSHSMSFISD 1525
            |.:|.:.:....||     ::..:|  |..|..:.:....:.|:...|..||.:.:..|.
Human   565 KTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSE----- 624

  Fly  1526 ANVLALHRLLWTHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVDSHMMFSSYARW 1590
                .:|.       |.|:....::....:|::.|.|                          ||
Human   625 ----PVHL-------KEGEMYKRAQGRTRIGKKNFKK--------------------------RW 652

  Fly  1591 SSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRYKIGETNGDLLI 1655
            ..:     ...|:....|...|:...|:...||.......:|.:            .:.|    :
Human   653 FCL-----TSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSF------------NKKN----M 696

  Fly  1656 YHVILTLKPFCHSPFEVVIDFTHTCSDNRFRTEFLQKWFYVLPTVAYENVHAVYIYNCNSWVREY 1720
            :.||.|.||....        .:.|.:       ..:|..||..|:          .||.  ...
Human   697 FQVIHTEKPLYVQ--------ANNCVE-------ANEWIDVLCRVS----------RCNQ--NRL 734

  Fly  1721 TKFHDRILAPLKGNRKLLFLESPNKL-----TDFIDAEQQKLPGATLSLDEDL---KVFS----N 1773
            :.:|..:.  |.||.........|.|     |..:.|:.|      :.:|||.   :::|    :
Human   735 SFYHPSVY--LNGNWLCCQETGENTLGCKPCTAGVPADIQ------IDIDEDRETERIYSLFTLS 791

  Fly  1774 ALKLSHKDT---KVAIKVGP 1790
            .|||...:.   .:|:..||
Human   792 LLKLQKMEEACGTIAVYQGP 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nf1	NP_733132.2	RasGAP_Neurofibromin	1242..1575	CDD:213332	77/342 (23%)
		CRAL_TRIO_2	1633..1767	CDD:404584	23/138 (17%)
		PH_NF1	1759..1868	CDD:270123	10/42 (24%)
		MOR2-PAG1_mid	<1931..>2109	CDD:372971
RASA2	XP_016862457.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940