DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nf1 and Iqgap2

DIOPT Version :9

Sequence 1:NP_733132.2 Gene:Nf1 / 43149 FlyBaseID:FBgn0015269 Length:2802 Species:Drosophila melanogaster
Sequence 2:XP_036013984.1 Gene:Iqgap2 / 544963 MGIID:2449975 Length:1612 Species:Mus musculus


Alignment Length:1977 Identity:374/1977 - (18%)
Similarity:661/1977 - (33%) Gaps:707/1977 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 QRVNEAALQNRHEPERCYFESLVIILTTLERCLTNQTKDTARFEEAMNVKLLLREISQFVDVQSD 126
            :.::|...||......|:.|.   ....:|.||..:...|...||.:...:.|.::::|.     
Mouse    63 EEMDERRRQNIAYEYLCHLEE---AKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFF----- 119

  Fly   127 SNPNAAQLKALASKVLFALSQNHFSAV---FNRISARIQELTSCSEENPDYNDIELIQHIDMDMI 188
                  ..|.::.|.::.:.|..:...   |......:|.|.:                  |:.|
Mouse   120 ------APKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRA------------------MEAI 160

  Fly   189 KLTKLL-QETITKFRSKRAPPLI-LLYSLEKAIWNWIEYHPQEFQDLQRG---TNRDISTCWEPL 248
            .|.|:. .||...:..|..|.:| .:::|...::. :...|| .|||...   |..:||...:.|
Mouse   161 GLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFK-LGIAPQ-IQDLLGKVDFTEEEISNMRKEL 223

  Fly   249 MDFVEYFKTENKKSKTLVWPL------------------------QMLLLILNPSCLEAVVNELQ 289
            ..:.......:|....|...|                        |.::.:.||:.:...|::..
Mouse   224 EKYGIQMPAFSKIGGILANELSVDEAALHAAVIAINEAIEKGVAKQTIITLRNPNAVLTCVDDSL 288

  Fly   290 QSEKEKE----KDKEKVASKSAQSTSRDKDFSAKQFIESIKRGLGQHSPSKQVTESAAIACVKLC 350
            ..|.:||    |.|::.::|...|...:::..|.:.:.:            |....:.|:.|...
Mouse   289 SQEYQKELWEAKKKKEESAKLKNSCISEEERDAYEELLT------------QAEIQSNISTVNRM 341

  Fly   351 KASTYIN----NTDSNNVVFKLVQFFINDLKALLFNPAKPFSRGQG-YNFADIELMIDCWVSCFR 410
            .|..:||    ..|..|.:..|               .||.::... |.||.:....:.:     
Mouse   342 AAVDHINAVLQEGDPENTLLAL---------------KKPEAQLPAVYPFAAVMYQNELF----- 386

  Fly   411 INPHNIEALKVCLNLSSPQAYHFVIVCSLLRLAHIYVDFRLQNKNPFRIVNQPRLSWWPQTDVVH 475
                         ||......::        |||..:...::..:...::||.            
Mouse   387 -------------NLQKQNTSNY--------LAHEELLIAVEMLSAVALLNQA------------ 418

  Fly   476 YRSAELRALFTDTLNKATQGY----IAHTPLRYITSLTLKSKDTQKGLTRAEEGPAHKMLLLLLV 536
            ..|::|.|: .:.|...|.|:    .||.. ||..:| |..|  |:.|::.::            
Mouse   419 LESSDLVAV-QNQLRSPTIGFNNLDEAHVD-RYADAL-LSVK--QEALSQGQD------------ 466

  Fly   537 RLIHADPTLLLNTQGKVAHEVQSSTLELINGLVSLVHQTTMPDVAQEAMEALLAL-HAPEKIEVW 600
                   ||..|       |:| :.:::||..:            ||..:.::.| :..|.|:..
Mouse   467 -------TLSWN-------EIQ-NCIDMINNQI------------QEENDRMVVLGYINEAIDAG 504

  Fly   601 NPEAPINTFWDVSSQVLFSISQKLIQHQIANYTDVLKWLREILICRNTFLQRHKDYAHVGSQIAI 665
            ||...::|....::.:. .:.....||    |.|||.:.:.         |:..|..:|..    
Mouse   505 NPLKTLDTLLLPTANIR-DVDPDCAQH----YQDVLFYTKS---------QKLGDPKNVSK---- 551

  Fly   666 CKQAHIKMEVVFFMYLWSVDLDAVLTSLSCFGLLCEEAEICCSSDELTVGFIMPNYHIYQELAQL 730
                          .||   ||.:..:::       ||.:    ||             ....|.
Mouse   552 --------------VLW---LDEIQQAIN-------EANV----DE-------------NRAKQW 575

  Fly   731 STSATDSRICFFDNTHGNVLSRLTLQKRIMTLLRKIEHCVHGVQPAWEETFRNWEVSSKVLQTYP 795
            .|...|...| .|....:         .|:|.|:.....:|.:.|         |.::|...|..
Mouse   576 VTLVVDVNEC-LDRKQSD---------HILTALKSSPSNIHNILP---------ECANKYYDTLV 621

  Fly   796 KCKGEDGQAEVFHRGMGKRRASHQSSEHDLEEQINEWANMTWFLLALGGVCLHKRSSSRQMLLQQ 860
            |.|              :.:..::|||       ..|..:.                     :|:
Mouse   622 KAK--------------ESKTDNESSE-------GSWVTLN---------------------VQE 644

  Fly   861 SQNNASLGSLAQNSLYSSSTSSGHGSLHPSTVSLST---LPPAPPQDVSYCPVTQFVGQLLRLLV 922
            ..|            |..:|.|..||..|..:.||.   |.....:|:    |.:.....:|   
Mouse   645 KYN------------YYYNTDSKEGSWVPPELCLSKESWLTGEEIEDI----VEEVTSDYIR--- 690

  Fly   923 CSNEKIGLNIQKNVKELVGEEMSTQLYP-----------ILFDQVRAIVE-----KFFDQQ---- 967
               ||    :....::|:....:|.|.|           .|::|..::|:     |.|.|:    
Mouse   691 ---EK----LWSASEDLLVRFEATTLGPALREEFEARKAFLYEQTESVVKIQAFWKGFKQRQEYL 748

  Fly   968 -------GQVNVNVTDINT----------------QFIEHTIYIMK--SILDPKANKDPNNDQPS 1007
                   |.|: :|..|.:                .|.:|...|:|  |:|.....:|       
Mouse   749 HRQQVFAGNVD-SVVKIQSWFRMVTARKSYLSRLRYFEDHKNEIVKIQSLLRASKARD------- 805

  Fly  1008 PSEHLGVTSIEGMMLGIVR-YVRHLDMTVYAIRIKTKLCQLVEVMMKRRDDLAFRQEMKFRNKLV 1071
              ::..:...|...|.::| :|..||                      :.||.|::|::......
Mouse   806 --DYKALVGSENPPLTVIRKFVYLLD----------------------QSDLDFQEELEVARLRE 846

  Fly  1072 EYLTDWVMGTSHQIAPPSSADAAILTNTSLIFRDLDQACMEAVAALLRGLPLQPEESDRGDLMDA 1136
            |.:|                  .|..|..|                         |.|. :|||.
Mouse   847 EVVT------------------KIRANQQL-------------------------EKDL-NLMDI 867

  Fly  1137 KSALFLKYFTLFMN--LLNDCIDSSEAEKEMNNTPLLPPRPRMAAGKLTALRNATILAMSNLLGA 1199
            |..|.:|      |  .|.|.|..   .|::|         :...|::..|.|.           
Mouse   868 KIGLLVK------NRITLEDVISH---RKKLN---------KKKGGEIEILNNT----------- 903

  Fly  1200 NIDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQQGTEFDTLAETVLADRFEQLVQLVTMISDKGE 1264
              |:..:.|:.......|:|    .:.|..:||  |:...||:.:.           .|..:|  
Mouse   904 --DNKGIKSLSKERRKTLET----YQQLFYLLQ--TKPSYLAKLIF-----------QMPQNK-- 947

  Fly  1265 LPIAMALANVVTTSQMDELARVLVTLFD------AKHLLSPLLWNMFYREVEVS-DCMQTLFRGN 1322
                       :|..||   .|:.||::      .::||..|.......|::.. |.:|.:..||
Mouse   948 -----------STKFMD---TVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTGN 998

  Fly  1323 SLGSK-IMAFCFKIYGASYLQMLLEPLIRPLLDEE-------------------EETCFEVDPAR 1367
            ....| :::|.....|.:.|:.||.|:::.:::::                   |....|.....
Mouse   999 PTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIEDKALVINTNPVEVYKAWVNQLETQTGEASKLP 1063

  Fly  1368 LDPTED-----------IEQHRNNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNL 1421
            .|.|.:           :|....||..:|.||..:||:|.|..|..||.:...|...:.::||:.
Mouse  1064 YDVTTEQALTYPEVKNKLEASIENLRKVTDKVLGSIISSLDLLPYGLRYIAKVLKNSIREKFPDA 1128

  Fly  1422 LQNN-IGAVGTVIFLRFINPAIVSPQELGIVDK----QVHSSAKRGLMLMSKILQNIANHVEFSK 1481
            .:.. :..||.:::.|::|||||:|....|:|.    |::|:.:|.|..::|:||:.|::..|..
Mouse  1129 TEEELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSNQRRNLGSVAKVLQHAASNKLFEG 1193

  Fly  1482 E-QHMLCFNDFLRDHFEAGRRFFIQIASDCETVDQ------------TSHSMSFISDANVLALHR 1533
            | :|:...|::|.:.::..|::| |.|.|....::            .|..:.:||...::..|.
Mouse  1194 ENEHLSSMNNYLSETYQEFRKYF-QEACDVPEPEEKFNMDKYTDLVTVSKPVIYISIEEIINTHL 1257

  Fly  1534 LLWTHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPVDSHMMFSSYARWSSIDMSST 1598
            ||..||:             |:.....|.:..||..||  |...|:      |:....::|.:..
Mouse  1258 LLLEHQD-------------AIATEKSDLLNELLESLG--EVPTVE------SFLGEGAVDPNDP 1301

  Fly  1599 NFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRYKIGE-TNGDLLIYHVILTL 1662
            |.|..:  :|:.     ||..|:::     |||  |.|        |.|| .:|..|   :|.|.
Mouse  1302 NKENTL--NQLS-----KTEISLSL-----TSK--YDV--------KDGEAVDGRSL---MIKTK 1341

  Fly  1663 KPFCHSPFEVVIDFTHTCSDNRFRTEFLQKWFYVLPTVAYENV-HAVYIYN---CNSWVREYTKF 1723
            |        ::||.|.....:.. ||.|:     .|....:.: ||..:.:   .:|...|..|.
Mouse  1342 K--------LIIDVTRNQPGSTL-TEILE-----TPATGQQELEHAKDMESRAVVDSRTPEEGKQ 1392

  Fly  1724 HDRIL----APL-----KGNRKLLFLE------SPNKLTDFI-----DAEQQ----KLPGATLS- 1763
            ...::    .||     |..|.|..||      |.||..|.:     |...|    ||..|.|| 
Mouse  1393 SQAVIEDARLPLEQKKRKIQRNLRTLEQTGHVSSKNKYQDILNEIAKDIRNQRIHRKLRKAELSK 1457

  Fly  1764 --------------LDEDLKVFSNALK-----LSHKDTKVAIKVGPTALQITSAEKTKVLAHSVL 1809
                          .::.:..:...:|     |..|:::.:||:...| :....::.|.:.    
Mouse  1458 LQQTLNALNKKAAFYEDQINYYDTYIKTCVDNLKRKNSRRSIKLDGKA-EPKGTKRVKPVR---- 1517

  Fly  1810 LNDVYYASEIEE--VCL-VDD---NQF 1830
                |.|:::.:  |.| :||   |||
Mouse  1518 ----YTAAKLHDKGVLLGIDDLQTNQF 1540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nf1NP_733132.2 RasGAP_Neurofibromin 1242..1575 CDD:213332 86/388 (22%)
CRAL_TRIO_2 1633..1767 CDD:404584 40/177 (23%)
PH_NF1 1759..1868 CDD:270123 19/98 (19%)
MOR2-PAG1_mid <1931..>2109 CDD:372971
Iqgap2XP_036013984.1 CH_SF 53..203 CDD:412120 31/173 (18%)
IQ 726..747 CDD:197470 5/20 (25%)
IQG1 <821..1612 CDD:227586 195/920 (21%)
RasGAP_IQGAP2 953..1311 CDD:213333 89/384 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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