| Sequence 1: | NP_733132.2 | Gene: | Nf1 / 43149 | FlyBaseID: | FBgn0015269 | Length: | 2802 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_002488.1 | Gene: | NEK2 / 4751 | HGNCID: | 7745 | Length: | 445 | Species: | Homo sapiens |
| Alignment Length: | 324 | Identity: | 62/324 - (19%) |
|---|---|---|---|
| Similarity: | 115/324 - (35%) | Gaps: | 96/324 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 28 GTQARMSQDQL-------------VACLIHISRYRFSLVISGLTKMLQRVNEAALQN---RHEPE 76
Fly 77 RCYFESLVIILT-----------TLERCLTNQ-TKDTARFEEAMNVKLLLREISQFVDVQSDSNP 129
Fly 130 NAAQLKALASKVLFALSQNHFSAVFNRISARIQELTSCSEENPDYNDIELIQHIDMDMIKLTKLL 194
Fly 195 QETITKFRSKRAPPLILLYSLEKAIWNWIEYHPQEFQDLQRGTNRDISTCWEPLMDFVEYFKTEN 259
Fly 260 KKSKTLVWPLQMLLLILNPSCLEAVVNELQQSEKEKEKDKEK---VASKSAQSTSR-DKDFSAK 319 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Nf1 | NP_733132.2 | RasGAP_Neurofibromin | 1242..1575 | CDD:213332 | |
| CRAL_TRIO_2 | 1633..1767 | CDD:404584 | |||
| PH_NF1 | 1759..1868 | CDD:270123 | |||
| MOR2-PAG1_mid | <1931..>2109 | CDD:372971 | |||
| NEK2 | NP_002488.1 | STKc_Nek2 | 7..271 | CDD:270857 | 20/97 (21%) |
| Interaction with PCNT. /evidence=ECO:0000269|PubMed:20599736 | 264..445 | 44/233 (19%) | |||
| Interaction with CEP85. /evidence=ECO:0000269|PubMed:26220856 | 301..445 | 36/195 (18%) | |||
| Leucine-zipper | 306..334 | 5/29 (17%) | |||
| Necessary for interaction with MAD1L1. /evidence=ECO:0000269|PubMed:14978040 | 329..445 | 31/165 (19%) | |||
| Required for microtubule binding and for localization to the centrosomes | 333..370 | 13/75 (17%) | |||
| Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000269|PubMed:21076410 | 403..439 | 12/35 (34%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG1826 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||