DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nf1 and raskol

DIOPT Version :9

Sequence 1:	NP_733132.2	Gene:	Nf1 / 43149	FlyBaseID:	FBgn0015269	Length:	2802	Species:	Drosophila melanogaster
Sequence 2:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	116/436 - (26%)
Similarity:	179/436 - (41%)	Gaps:	66/436 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1197 LGANIDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQQGTEFDTLAETVLADRFEQLVQLVTMISD 1261
            ||.....|...|.|....|.|:.:..|..  |.||......:.|  |.|.:.::::.:
  Fly   840 LGRTSGGGGSGSKDKEQLPTLRIKCRFQS--TDILPINVYGNFL--TYLKENYKRVCE------- 893

  Fly  1262 KGELPIAMALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYRE-VEVSDCMQTLFRGNSLG 1325
                    .|..|:.....:::.:.||.|..|:.|....|.::...: :.|.| .:..||||||.
  Fly   894 --------TLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLA 949

  Fly  1326 SKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTE--DIEQHRNNLIALTQKV 1388
            :|.|....|:.|..|||..|...|..|:..|.: | ||||.:...:.  .:::.:..|....:..
  Fly   950 TKSMEAFLKLTGEQYLQDTLSAPINELIQSERD-C-EVDPTKTSGSSAGSLQRQQAALRGAVRGA 1012

  Fly  1389 FDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNL----LQNNIGAVGTVIFLRFINPAIVSPQELG 1449
            :..|..|...||.|||: |...::   :|...|    :.:|:  :...|||||:.|||:||....
  Fly  1013 WQCIFESHKHFPAQLRN-CFATFR---ERLQQLGRQDMADNL--ISASIFLRFLCPAILSPSLFN 1071

  Fly  1450 IVDKQVHSSAKRGLMLMSKILQNIANHVEF-SKEQHMLCFNDFLRDHFEAGR-RFFIQIAS---D 1509
            |..:...:.|.|.|.|::|.||.:||...| .||..|...||||..  ||.| :.|::|.|   :
  Fly  1072 ITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQ--EAARMQQFLEIISTRPE 1134

  Fly  1510 CETVDQTSHSMSFISDANVLA-LHRLLWTHQEKIGDYLSSSRDHK---------AVGRRPFDKMA 1564
            ....|.......:|.....|: ||.||.....|    |..:|.|:         .:.|.....|.
  Fly  1135 HPAPDSILDWAGYIDQGKQLSILHSLLSESLAK----LPEARQHELDPLQHILDEISRAKEHGMG 1195

  Fly  1565 TLLAYLGPPEHKPVDS--HMMFSSYAR----WSSIDMSSTNFEEIM 1604
            |.|    |..:.|..|  |.:.|....    .||...:.:|.|:::
  Fly  1196 TAL----PGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLL 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nf1	NP_733132.2	RasGAP_Neurofibromin	1242..1575	CDD:213332	96/354 (27%)
		CRAL_TRIO_2	1633..1767	CDD:404584
		PH_NF1	1759..1868	CDD:270123
		MOR2-PAG1_mid	<1931..>2109	CDD:372971
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082
		PH	<656..720	CDD:278594
		C2_SynGAP_like	721..874	CDD:175980	11/35 (31%)
		RasGAP	856..1185	CDD:214617	98/362 (27%)
		RasGAP_DAB2IP	865..1192	CDD:213338	97/360 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940