DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nf1 and gap1

DIOPT Version :9

Sequence 1:NP_733132.2 Gene:Nf1 / 43149 FlyBaseID:FBgn0015269 Length:2802 Species:Drosophila melanogaster
Sequence 2:NP_001342789.1 Gene:gap1 / 2540440 PomBaseID:SPBC646.12c Length:766 Species:Schizosaccharomyces pombe


Alignment Length:801 Identity:166/801 - (20%)
Similarity:308/801 - (38%) Gaps:229/801 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1187 NATILAMSN---LLGANIDSGLMHSIDLGYNPDLQTRAAFM-------EVLTQILQQGTE----- 1236
            ::::|..:|   ||.....:.::::|||....|::.  ||.       ::..||..|..:     
pombe    10 SSSVLPQTNRLSLLRNRESTSVLYTIDLDMESDVED--AFFHLDRELHDLKQQISSQSKQNFVLE 72

  Fly  1237 -----FDTLAETVLADRF--EQLVQLVTMISD-----KGELP---------------------IA 1268
                 .|:....::.:|.  |:..:....::|     ||..|                     ||
pombe    73 RDVRYLDSKIALLIQNRMAQEEQHEFAKRLNDNYNAVKGSFPDDRKLQLYGALFFLLQSEPAYIA 137

  Fly  1269 MALANVVTTSQMDELARVLVTLFD---------AKHLLSPLLWNMFYREVEVSDCMQTLFRGNSL 1324
             :|...|....||.|.:::  :|:         .:|||..|...:...|.|.:..:.:|.|.|:.
pombe   138 -SLVRRVKLFNMDALLQIV--MFNIYGNQYESREEHLLLSLFQMVLTTEFEATSDVLSLLRANTP 199

  Fly  1325 GSKIM-AFCFKIYGASYLQMLLEPLIRPL-------LDEEEETCFE--VDPARLDPTED------ 1373
            .|::: .:..:..|.:||:.:|...|..:       ||....:.:.  |:..:|.|:||      
pombe   200 VSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTGQLSPSEDDNLLTN 264

  Fly  1374 ------------IEQHRNNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNI 1426
                        |::....|:.||::..||::||.|..|..:|.:|..:..:.::.||::..:.|
pombe   265 EEVSEFPAVKNAIQERSAQLLLLTKRFLDAVLNSIDEIPYGIRWVCKLIRNLTNRLFPSISDSTI 329

  Fly  1427 -GAVGTVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKILQNIANHVEFSKEQHMLCFND 1490
             ..:|...||||:||||:|||...::|.....:.::.|..::||:|::||....:|....:.|..
pombe   330 CSLIGGFFFLRFVNPAIISPQTSMLLDSCPSDNVRKTLATIAKIIQSVANGTSSTKTHLDVSFQP 394

  Fly  1491 FLRDHFEAGRRFFIQIAS-----DCETVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYLSSSR 1550
            .|:::.|.......::.:     :...:||.. ::|..|.|..:.::.:..|| |.|.:.|.:..
pombe   395 MLKEYEEKVHNLLRKLGNVGDFFEALELDQYI-ALSKKSLALEMTVNEIYLTH-EIILENLDNLY 457

  Fly  1551 DHKAVGRRPFDKMATLLAYLGPP-EHKPVDSHMMFS--SYARW-SSI-DMSSTNFEEIMVKHQMH 1610
            |       |...:..:|..||.| :..|.:.:.:.:  .|.|| ||| |:               
pombe   458 D-------PDSHVHLILQELGEPCKSVPQEDNCLVTLPLYNRWDSSIPDL--------------- 500

  Fly  1611 EKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHSPFEVVID 1675
             |:..|..:...::..|.|                         ::..:|.|.|..|....|.:|
pombe   501 -KQNLKVTREDILYVDAKT-------------------------LFIQLLRLLPSGHPATRVPLD 539

  Fly  1676 FTHTCSDNRFRTEFLQKWFYVLPTVA------------YENVHAVYIYNCNSWVREYTKFHDRIL 1728
                                 ||.:|            .:.:.|:.:.:..|.:|...|  :...
pombe   540 ---------------------LPLIADSVSSLKSMSLMKKGIRAIELLDELSTLRLVDK--ENRY 581

  Fly  1729 APLKGNRKLLFLESPNKLTDFIDAEQQKLPGATLS-------LDEDLKVF----SNA---LKLSH 1779
            .||....:..|::. :.|.:.|.||:..|.....:       |...|:::    :||   :|.||
pombe   582 EPLTSEVEKEFIDL-DALYERIRAERDALQDVHRAICDHNEYLQTQLQIYGSYLNNARSQIKPSH 645

  Fly  1780 KDTK-----VAIKVGPTALQITSAEKTKVLA-----HSVLLNDVYYASEIEEVCLVDDNQFTLSI 1834
            .|:|     |.: ||.....|.|:...|:.:     .|||||           |.:.  :|.:|.
pombe   646 SDSKGFSRGVGV-VGIKPKNIKSSNTVKLSSQQLKKESVLLN-----------CTIP--EFNVSN 696

  Fly  1835 TNESGQLSFIHNDCDNIVQAI 1855
            |    ..:|.....||.|.|:
pombe   697 T----YFTFSSPSTDNFVIAV 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nf1NP_733132.2 RasGAP_Neurofibromin 1242..1575 CDD:213332 90/404 (22%)
CRAL_TRIO_2 1633..1767 CDD:404584 22/152 (14%)
PH_NF1 1759..1868 CDD:270123 29/121 (24%)
MOR2-PAG1_mid <1931..>2109 CDD:372971
gap1NP_001342789.1 RasGAP_C <1..766 CDD:332048 166/801 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 72 1.000 Domainoid score I2593
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm47359
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.030

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