DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nf1 and Rasa3

DIOPT Version :9

Sequence 1:NP_733132.2 Gene:Nf1 / 43149 FlyBaseID:FBgn0015269 Length:2802 Species:Drosophila melanogaster
Sequence 2:NP_033051.2 Gene:Rasa3 / 19414 MGIID:1197013 Length:834 Species:Mus musculus


Alignment Length:879 Identity:175/879 - (19%)
Similarity:304/879 - (34%) Gaps:290/879 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   926 EKIGLNIQKNVKELVGEEMSTQLYP-----------ILFDQVRA----IVEK----FF--DQQGQ 969
            |:.||.:.::|:..:||..:...||           :..||...    ||||    |:  |...:
Mouse     4 EEEGLRVFQSVRIKIGEAKNLPSYPGPNKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCE 68

  Fly   970 VNVNVTDINTQFIEHTIYIMKSILDPKA------NKDPNNDQPSPSEHLGVTS-IEGMMLGIVRY 1027
            :..:...::....:..::...||:...|      .:..|.|.....:|:...| ::|.:      
Mouse    69 IPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKV------ 127

  Fly  1028 VRHLDMTVYAIRIKT-----KL------CQLVEVMMKRRDDLA-------FRQEMKFRNKLVEYL 1074
              ||::.:..:...|     ||      ||.:.::..:.|..|       ||.|.| :.|:.:  
Mouse   128 --HLELRLSEVITDTGVVCHKLAARIFECQGLPIVNGQCDPYATVTLAGPFRSEAK-KTKVKK-- 187

  Fly  1075 TDWVMGTSHQIAPPSSADAAILTNT----SLIFRDLDQACMEAVAALLRGLPLQPEESD----RG 1131
                                 .||.    .:.:.::.:.|..:..:   ....:.|:.|    |.
Mouse   188 ---------------------KTNNPQFDEVFYFEVTRPCSYSKKS---HFDFEEEDVDKLEIRV 228

  Fly  1132 DLMDAKSAL----FLKYFTLFMNLLNDCIDSSEA-----EKEMNNTPLLPPRPRMAAGKLTALRN 1187
            ||.:|.:..    ||....|.:.:|... .|.||     .::..|..|.|       ..|.:||.
Mouse   229 DLWNASNLKFGDEFLGELRLPLKILRHS-SSYEAWYFLQPRDNGNKSLKP-------DDLGSLRL 285

  Fly  1188 ATILAMSNLLGANIDSGLMHSIDLGYNP--DLQTRAAFMEVLTQILQQGTEFDTLAETVLADRFE 1250
            ..:....::..:..           |:|  ||..::|.:|.::     .:....|.| |..|:.|
Mouse   286 NVVYTEDHVFSSEY-----------YSPLRDLLLKSADVEPVS-----ASAAHILGE-VCRDKQE 333

  Fly  1251 QLVQLVTMISDKGE-LPIAMALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVSDC 1314
            ..:.||.::...|. :|...|:|:.                                 ||:.:..
Mouse   334 AAIPLVRLLLHYGRVVPFISAIASA---------------------------------EVKRTQD 365

  Fly  1315 MQTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIEQHRN 1379
            ..|:||||||.||.:....|:.|..||.:.|:|.|..:. :..::| |:||.:|...|::|.:..
Mouse   366 PNTIFRGNSLTSKCIDETMKLAGMHYLHVTLKPTIEEIC-QSHKSC-EIDPVKLKDGENLENNME 428

  Fly  1380 NLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIGAVGTVIFLRFINPAIVS 1444
            :|.....::|..|..|....|..:..:...|.:..:|||.:.|.....||.:.|||||..|||:|
Mouse   429 SLRQYVDRIFTVITKSGVSCPTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILS 493

  Fly  1445 PQELGIVDKQVHSSAKRGLMLMSKILQNI-----ANHVEFSKEQHMLCFNDFLRD--HFEAGRRF 1502
            |....:..........|.|.|:||.:|.:     :....| ||.:|..|.:|..:  :.:|.:.|
Mouse   494 PNLFQLTPHHTDPQTSRTLTLISKTIQTLGSLSKSKSASF-KESYMATFYEFFNEQKYADAVKNF 557

  Fly  1503 FIQIAS----DCETVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYLSSSRDHKAVGRRPFDKM 1563
            ...|:|    |.::::|..                ||     |.|..:..::..|..|.:.|.| 
Mouse   558 LDLISSSGRRDPKSIEQPI----------------LL-----KEGFMIKRAQGRKRFGMKNFKK- 600

  Fly  1564 ATLLAYLGPPEHKPVDSHMMFSSYARWSSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQAG 1628
                                     ||..:    ||.|                     ..||  
Mouse   601 -------------------------RWFRL----TNHE---------------------FTYQ-- 613

  Fly  1629 TSKSGYPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHSPFEVVIDFTHTCSDNRFRTEFLQKW 1693
                               ::.||          :|.|:.|.|.:: ......:..||   ::..
Mouse   614 -------------------KSKGD----------QPLCNIPIENIL-AVERLEEESFR---MKNM 645

  Fly  1694 FYVLPTVAYENVHAVYIY--NC---NSWVREYTK 1722
            |.|:     :...|:||.  ||   ..|:...||
Mouse   646 FQVI-----QPERALYIQANNCVEAKDWIDILTK 674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nf1NP_733132.2 RasGAP_Neurofibromin 1242..1575 CDD:213332 83/344 (24%)
CRAL_TRIO_2 1633..1767 CDD:404584 18/95 (19%)
PH_NF1 1759..1868 CDD:270123
MOR2-PAG1_mid <1931..>2109 CDD:372971
Rasa3NP_033051.2 C2A_RasA2_RasA3 13..133 CDD:176046 23/127 (18%)
C2B_RasA3 146..288 CDD:175977 33/176 (19%)
RasGAP 275..614 CDD:214617 102/491 (21%)
RasGAP_RASA3 297..565 CDD:213336 80/320 (25%)
PH_GAP1_mammal-like 562..686 CDD:241522 36/225 (16%)
PH 577..676 CDD:278594 33/194 (17%)
BTK 679..714 CDD:128417
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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