DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nf1 and gap-1

DIOPT Version :9

Sequence 1:	NP_733132.2	Gene:	Nf1 / 43149	FlyBaseID:	FBgn0015269	Length:	2802	Species:	Drosophila melanogaster
Sequence 2:	NP_508404.1	Gene:	gap-1 / 180530	WormBaseID:	WBGene00001515	Length:	629	Species:	Caenorhabditis elegans

Alignment Length:	611	Identity:	122/611 - (19%)
Similarity:	232/611 - (37%)	Gaps:	143/611 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1249 FEQLVQLVTMISDKGELPIAM-ALANVVTTSQMDELARVLVTLFDAKHLLSPLLWNMFYREVEVS 1312
            ::.|:.|:.:..|...|..:: |:...:...::..::|.||.|......:.|:|.:::...:...
Worm   136 YKPLLDLLFLAGDVQPLTASLVAVIEALPKVELGPVSRSLVELMAQSDRIRPVLSSLYVNSILKC 200

  Fly  1313 DCMQTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIEQH 1377
            ....|||||.||..|::......||..||...|:|::..:. :|.:.| ||||||:.....:|::
Worm   201 QDENTLFRGQSLSGKMLFEILTTYGKMYLITTLKPVVDKIY-KERKNC-EVDPARVAVGASLEKN 263

  Fly  1378 RNNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIG-----------AVGT 1431
            ||||:...|.:|:.:..||...|       |.:.|:|..     |:|.:|           ||.:
Worm   264 RNNLLVYFQMLFERVTTSSTNCP-------HLIKQLLYD-----LRNVVGTHSSRSGVQRLAVSS 316

  Fly  1432 VIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKILQNIANHVEFSKEQHMLCFNDFLRDHF 1496
            .:.:||...||::|:...|...|......|.|:|:||:||.::|   .|..:..|...:
Worm   317 FVIMRFFAAAILNPKAFEIRKDQPDLRVSRTLLLLSKLLQRLSN---CSVSEGPLSSKE------ 372

  Fly  1497 EAGRRFFIQIASDCETVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYLSSSRDHKAVGRRPFD 1561
                   |.:....|||....|.....|..:.::|                       ||.|...
Worm   373 -------IWLNGVFETVTSEQHKSVMASFLDNISL-----------------------VGDRSEP 407

  Fly  1562 KMATLLAYLGPPEHKPVDSHMMFSSYARWSSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQ 1626
            :..|:.                  .:.....:|.|...::::     :|.|:.:..|.:.::.:|
Worm   408 QKCTVF------------------KFGNLQQVDRSRLAWKKV-----LHYKKRYVQLTNTHLIWQ 449

  Fly  1627 AGTS---KSGYPVFYYIARRYKIGETNGDLLIYHVILTLKPFCHSPFEV-VIDFTHTCSDNRFR- 1686
            ....   |...|:     ...|....:...:|..|..|::....:|..| ..|:.:.....|.|
Worm   450 KDVQCAPKGTVPL-----SDIKFVNVDNKNIITIVCETMQLQFEAPGGVEATDWLNAIERQRNRA 509

  Fly  1687 ----TEFLQKWFYVLPTVAYENVHA-VYIYNCNSWVREYTKFHDRILAPLKGNRKLLFLESPNKL 1746
                .|...:.|:|......:.:|. :|.|      ||                  ..:|..::|
Worm   510 AHEIAETPGEHFFVDAERHVDKIHTLLYKY------RE------------------TMIEWRDQL 550

  Fly  1747 TDFIDAEQQKLP---GATLSLDEDLKVFSNALKLSHKDTKVAIKVGPTALQITSAEKTKVLAHSV 1808
            ...::.:::..|   .|:..::|:        :.||||:.:|...  :.:.:|.|.:   |||:.
Worm   551 QSNVELDEKTAPELLKASYVVEEE--------RQSHKDSLIATLC--STIDVTDAIQ---LAHTE 602

  Fly  1809 LLNDVYYASEIEEVCLVDDNQFTLSI 1834
            ...:...:..|:.:......|.:.|:
Worm   603 YEKENKVSRRIDAIITAKKRQKSFSV 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nf1	NP_733132.2	RasGAP_Neurofibromin	1242..1575	CDD:213332	79/337 (23%)
		CRAL_TRIO_2	1633..1767	CDD:404584	22/143 (15%)
		PH_NF1	1759..1868	CDD:270123	15/76 (20%)
		MOR2-PAG1_mid	<1931..>2109	CDD:372971
gap-1	NP_508404.1	RasGAP	119..459	CDD:214617	86/398 (22%)
		RasGAP_GAP1_like	134..401	CDD:213330	75/317 (24%)
		PH	424..504	CDD:214574	14/89 (16%)
		PH	434..504	CDD:278594	12/74 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R472
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940