|
Fly 4 KPGEWASALLARFEDQLPNRIGAYGTQARMSQDQLVACLIHISRYRFSLVISGLTKMLQRVNEAA 68
:|.||..|:::||::|||.:.|...|..::|.:....|||:||:|:|||||||||.:|:.||...
Mouse 5 RPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTTILKNVNNMR 69
Fly 69 LQNRHEPERCYFESLVIILTTLERCLTNQTKDTARFEEAMNVKLLLREISQFVDVQSDSNPNAAQ 133
:......:..|...| |||.|||:||..|.|||.|.:|.|.||.||.||..|:....:.|.:||:
Mouse 70 IFGEAAEKNLYLSQL-IILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAE 133
Fly 134 LKALASKVLFALSQNHFSAVFNRISARIQELTSCSEENPDYNDIELIQHIDMDMIKLTKLLQETI 198
|:..||.|||:||.|:|:|||:|||.|:||||.|||:|.|.:||||:|:|::|..||.:||:||.
Mouse 134 LRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETA 198
Fly 199 TKFRS-KRAPPLILLYSLEKAIWNWIEYHPQEFQDLQRGTNRDISTCWEPLMDFVEYFKTENKKS 262
.||:: |:...|.::.|||||.|||:|.:|.||..|.:....|::.|.|.|.|.|:.| .|:.|.
Mouse 199 FKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQTDMAECAEKLFDLVDGF-AESTKR 262
Fly 263 KTLVWPLQMLLLILNPSCLEAVVNELQQSEKEKEKDKEKVASKSAQSTSRDKDFSAKQFIESIKR 327
|..|||||::||||.|..::.:..::.. :.:.:.|.|::|:::
Mouse 263 KAAVWPLQIILLILCPEIIQDISKDVVD----------------------ESNINKKLFLDSLRK 305
Fly 328 GLGQHSPSKQVTESAAIACVKLCKASTYINNTDSNNVVFKLVQFFINDLKALLFNPAKPFSRGQG 392
.|..|..|:|:|||||||||||||||||||..| |:|:|.|||..:.|||.|||||:||||||.
Mouse 306 ALAGHGGSRQLTESAAIACVKLCKASTYINWED-NSVIFLLVQSMVVDLKNLLFNPSKPFSRGS- 368
Fly 393 YNFADIELMIDCWVSCFRINPHNIEALKVCLNLSSPQAYHFVIVCSLLRLAHIYVDFRLQNKNPF 457
..||::|||||.||||||:|||.:..|:||..:||..:|:|:|.|| .|:...:.|
Mouse 369 -QPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSL---------HRIITNSTF 423
Fly 458 R--IVNQPRLSWWPQTDVVHYRSAELRALFTDTLNKATQGYIAHTPLRYITSLTLKSKDTQKGLT 520
: :.....|.|||:.|.|:..|.|||.:|.:||:||.||..||..:|...|||.|.|.|. .
Mouse 424 KHGLGTASALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTS---L 485
Fly 521 RAEEGP------AHKMLLLLLVRLIHADPTLLLNTQGKVAHEVQSSTLELINGLVSLVHQTTMPD 579
:.:|.| ::|.|||.:|:||||||.|||....|...|.||||.|||.|||.||.|:.||:
Mouse 486 KFKEKPTDLETRSYKCLLLSMVKLIHADPKLLLCNPRKQGPETQSSTAELITGLVQLVPQSHMPE 550
Fly 580 VAQEAMEALLALHAPEKIEVWNPEAPINTFWDVSSQVLFSISQKLIQHQIANYTDVLKWLREILI 644
||||||||||.||..:.|::|||:||:.|||::|||:||.|.:||..||:.:.|::|||||||||
Mouse 551 VAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWLREILI 615
Fly 645 CRNTFLQRHKD---------YAH-VGSQIA----------------------------------- 664
|||.||.::|. |.: ||.:::
Mouse 616 CRNKFLLKNKQADRSSCHSLYLYGVGCEMSATGNTTQMSVDHDEFLRACTPGASLRKGRGNSSMD 680
Fly 665 ----------ICKQAHIKMEVVFFMYLWSVDLDAVLTSLSCFGLLCEEAEICCSSDELTVGFIMP 719
||:||..|:||..:|:||:.|.:|||.::|||..|||||:|.|..||::|...:|
Mouse 681 STAGCSGTPPICRQAQTKLEVALYMFLWNPDTEAVLVAMSCFRHLCEEADIRCGVDEVSVHNFLP 745
Fly 720 NYHIYQELAQLSTSATDSRICFFDNTHGNVLS--RLTLQKRIMTLLRKIEHCVHGVQPAWEETFR 782
||:.:.|.|.:| |::| |..||||:|.|||:|||...|...|||:|..
Mouse 746 NYNTFMEFASVS----------------NMMSTGRAALQKRVMALLRRIEHPTAGNIEAWEDTHA 794
Fly 783 NWEVSSKVLQTYPKCKGEDGQ-AEVFHRGMGKRRASHQSSEHDLE----EQINEWANMTWFLLAL 842
.||.::|::..|||.|.|||| ||..|:.:.|||.||.|....:: :.:.||.|||.||.||
Mouse 795 KWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWINMTGFLCAL 859
Fly 843 GGVCLHKRSSSRQMLLQQSQNNASLGSLAQNSLYSSSTSSGHGSLHPSTVSLSTLPPAPPQDVSY 907
|||||.:|||| ..:..:..:|::::......|..|..|::.
Mouse 860 GGVCLQQRSSS-----GLATYSPPMGAVSERKGSMISVMSSEGNID------------------- 900
Fly 908 CPVTQFVGQLLRLLVCSNEKIGLNIQKNVKELVGEEMSTQLYPILFDQVRAIVEKFFDQQGQVNV 972
.||::|:.:||.|:||::||:||.|:.|||:|||.|:|..|||:||::::..:.||||.||| |
Mouse 901 SPVSRFMDRLLSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQ--V 963
Fly 973 NVTDINTQFIEHTIYIMKSILDPKANKDPNNDQPSPSEHLGVTSIEGMMLGIVRYVRHLDMTVYA 1037
.::|.||||:|.||.|||::|| |.....|||||..|||.|||.:|||||.|...|:|
Mouse 964 LLSDSNTQFVEQTIAIMKNLLD--------NHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHA 1020
Fly 1038 IRIKTKLCQLVEVMMKRRDDLAFRQEMKFRNKLVEYLTDWVMGTSHQIAPPSSADAAILTNTSLI 1102
|:|||||||||||||.|||||:|.||||||||:||||||||||||:|.| ..|...||
Mouse 1021 IQIKTKLCQLVEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAA---DDDIKCLT----- 1077
Fly 1103 FRDLDQACMEAVAALLRGLPLQPEESDRGDLMDAKSALFLKYFTLFMNLLNDCIDSSEAEKEMNN 1167
||||||.||||.:||.||||||||.|..:||:|||.|||||||||||||||| ||.|.|...
Mouse 1078 -RDLDQASMEAVVSLLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDC---SEVEDENAQ 1138
Fly 1168 TPLLPPRPRMAAGKLTALRNATILAMSNLLGANIDSGLMHSIDLGYNPDLQTRAAFMEVLTQILQ 1232
| ..|.|..:.:|.:||:.|:|||||||.||:||||||||.|||:.||||||.||||||:|||
Mouse 1139 T---GGRKRGMSRRLASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQ 1200
Fly 1233 QGTEFDTLAETVLADRFEQLVQLVTMISDKGELPIAMALANVVTTSQMDELARVLVTLFDAKHLL 1297
||||||||||||||||||:||:||||:.|:|||||||||||||..||.||||||||||||::|||
Mouse 1201 QGTEFDTLAETVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLL 1265
Fly 1298 SPLLWNMFYREVEVSDCMQTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLL--DEEEETC 1360
..||||||.:|||::|.||||||||||.||||.||||:|||:|||.||:||:|.:: .:.:...
Mouse 1266 YQLLWNMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRVIITSSDWQHVS 1330
Fly 1361 FEVDPARLDPTEDIEQHRNNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQ------------- 1412
|||||.||:|:|.:|:::.||:.:|:|.|.|||:||..||.||||:||||||
Mouse 1331 FEVDPTRLEPSESLEENQRNLLQMTEKFFHAIISSSSEFPSQLRSVCHCLYQATCHSLLNKATVK 1395
Fly 1413 --------VLSKRFPNLLQNNIGAVGTVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKI 1469
|:|:||| ||:|||||:.:||||||||||||.|.||:||:.....:|||.||||:
Mouse 1396 ERKENKKSVVSQRFP---QNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKV 1457
Fly 1470 LQNIANHVEFSKEQHMLCFNDFLRDHFEAGRRFFIQIASDCETVDQTSHSMSFISDANVLALHRL 1534
||:|||||.|:||:||..||||::.:|:..||||:.|||||.|.|..:||:|||||.||||||||
Mouse 1458 LQSIANHVLFTKEEHMRPFNDFVKSNFDLARRFFLDIASDCPTSDAVNHSLSFISDGNVLALHRL 1522
Fly 1535 LWTHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHKPV-DSHMMFSSYARWSSIDMSST 1598
||.:|||||.||||:||||||||||||||||||||||||||||| |:| |||::::|:
Mouse 1523 LWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH--------WSSLNLTSS 1579
Fly 1599 NFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIARRYKIGETNGDLLIYHVILTLK 1663
.|||.|.:||:|||||||.||:::|||||||||:|.|:|||:|||:|.|:.|||||||||:||||
Mouse 1580 KFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQINGDLLIYHVLLTLK 1644
Fly 1664 PFCHSPFEVVIDFTHTCSDNRFRTEFLQKWFYVLPTVAYENVHAVYIYNCNSWVREYTKFHDRIL 1728
|:...|:|:|:|.|||...|||:|:||.|||.|.|..||:||.||||||||||||||||:|:|:|
Mouse 1645 PYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVYIYNCNSWVREYTKYHERLL 1709
Fly 1729 APLKGNRKLLFLESPNKLTDFIDAEQQKLPGATLSLDEDLKVFSNALKLSHKDTKVAIKVGPTAL 1793
..|||:::|:|::.|.||.:.|:.||||||.|||:|:||||||.|||||:||||||:||||.||:
Mouse 1710 TGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLKVFHNALKLAHKDTKVSIKVGSTAV 1774
Fly 1794 QITSAEKTKVLAHSVLLNDVYYASEIEEVCLVDDNQFTLSITNESGQLSFIHNDCDNIVQAIIHI 1858
|:||||:||||..||.|||:||||||||:||||:|||||:|.|:...|:|:|.:|:.|||:||||
Mouse 1775 QVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQFTLTIANQGTPLTFMHQECEAIVQSIIHI 1839
Fly 1859 RNRWELSQPDSVTVHQKIRPKDVPGTLLNMALLNLGSCDPNLRTAAYNLLCALTATFDLKIEGQL 1923
|.|||||||||:..|.|||||||||||||:|||||||.||:||:||||||||||.||:|||||||
Mouse 1840 RTRWELSQPDSIPQHTKIRPKDVPGTLLNIALLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQL 1904
Fly 1924 LETQGLCIPSNNTIFIKSVSEKLATNEPHLTLEFLEESIQGFQRSTIELKHLCLEYMTPWLKNLV 1988
|||.|||||:|||:||.|:|:.||.||||||||||||.|.||.:|:|||||||||||||||.|||
Mouse 1905 LETSGLCIPANNTLFIVSISKTLAANEPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLV 1969
Fly 1989 KFCKSNDDSKKLKVSQILDKLINLTIDQKEMYPSVQAKIWGSIGQIPELIDMVLDNFLHKSITYG 2053
:|||.|||:|:.:|:.||||||.:||::|:||||:|||||||:|||.:|:|:|||:|:..|.|.|
Mouse 1970 RFCKHNDDAKRQRVTAILDKLITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGG 2034
Fly 2054 LGSPQVEIMADTAVALASANVQLVSKKVITRICRVMDKSCTNPTQYLEQHMMWDDIAILGRYLLM 2118
|||.:.|:||||||||||.||:|||.|||.|:|:::||:|.:||..||||:||||||||.||:||
Mouse 2035 LGSIKAEVMADTAVALASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLM 2099
Fly 2119 LSFNNCLDVATSVPYLFHTITFLVCSGSLSMRASTHGLVINIIHSLCTCTNPSFSEEAQRVLRLS 2183
|||||.||||..:|||||.:||||.:|.||:|||||||:||||||||||:...||||.::|||||
Mouse 2100 LSFNNSLDVAAHLPYLFHVVTFLVATGPLSLRASTHGLLINIIHSLCTCSQLHFSEETKQVLRLS 2164
Fly 2184 LDEFSLPKFYLLFGISKVKSAAVTAFRSSCRHPTDKWLGNERVTQPLPADRERLSLPSLEVITDA 2248
|.|||||||||||||||||||||.|||||.| :|...|...:||..:|.|||.:|:|
Mouse 2165 LTEFSLPKFYLLFGISKVKSAAVIAFRSSYR---------DRSFSPGSYERETFALTSLETVTEA 2220
Fly 2249 LLEIMEACMRDVPDCEWLNTWTSLARSFAFCYNPALQPRALIVYGCISKSVTDHEVKQLLRILVK 2313
|||||||||||:|.|:||:.||.||:.|||.|||:||||||:|:|||||.|:..::||::|||.|
Mouse 2221 LLEIMEACMRDIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSK 2285
Fly 2314 ALES-------FNDLILIEALVMCLTRIQPLLRPESPIHRALFWVAISVLQLDEITLYGAGLALL 2371
|||| :|..:|||:.|:.||::||||..:||:|:||||||::||||||:.||.||.|||
Mouse 2286 ALESCLKGPDTYNSQVLIESTVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL 2350
Fly 2372 EQNLHTLKSQGCFDKKETIAEVMMKTREKLEWHFKQLDHAVGLSFRSNFHFALVGHLIKGFRHPT 2436
|||||||.|...|:.|.. .||.|..|..||||.||:||.|||:|.|||:|||||||:||:|||:
Mouse 2351 EQNLHTLDSLRIFNDKSP-EEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGYRHPS 2414
Fly 2437 PTTVSRTSRVLTMLLGIIAKPLHRDKFEVTPDSVAYLTALVAVSEEVRSRCHVKHALPRWPADLS 2501
|..|:||.|:|..||.::.|..:.|||||...|||||.||:.|||||||||.:||.......|:
Mouse 2415 PAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLLTDI- 2478
Fly 2502 SSVEN-------------------------------GEASGGVQAIGLPLSRRQKSWDILDQSAL 2535
|:|| |..:....|:|....|.:||.. ||...
Mouse 2479 -SMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPAVGQTSPRARKSMS-LDMGQ- 2540
Fly 2536 QFARQHKVPTLQNARVLFKTQRSFS--VPTTKDPNNATGIEERQERGS----------------- 2581
|:..|.:.|..|::||. :..||.| :|||..|
Mouse 2541 --------PSQANTKKLLGTRKSFDHLISDTKAP-------KRQEMESGITTPPKMRRVAETDYE 2590
Fly 2582 -----------------RSSVSNESNVLLDPEVLPDLSIQALVLTVLATLVKYSSDEGETRVLYQ 2629
:.||| |||||||.|||.|..||||:||||||||||::||.:.|:||:
Mouse 2591 MAETQRIPSSQQHPHLRKVSVS-ESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYE 2654
Fly 2630 YLAEGSVVFPKVFPVIHSLLDQKINNILSVSHDQVVLNSVQNIIQNMLASED-PSQQQLHFLQSC 2693
||||.||||||||||:|:|||.|||.:||:..|..:||.:..|:|:::..|: |.|.|..:|||.
Mouse 2655 YLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSF 2719
Fly 2694 GFGGLWRFAGPFTKYNMMGESSELFVNCLEAMVETCLPG------DESAPVPPSPRPYNLSSSLS 2752
||.|||||||||:|...:.:.:||.|..|:|:::|.||| :||...|.||.|..|.|.|
Mouse 2720 GFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQL- 2783
Fly 2753 SLTLGSPTDKAFSSESLDFYDNCPGSVSSLRRASHSKSRAKHRINDSPS 2801
|:|... |...|::||..:.||....|..:..||:
Mouse 2784 SITANL---------------NLSNSMTSLATSQHSPGLDKENVELSPT 2817
| 
