DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nf1 and Nek2

DIOPT Version :9

Sequence 1:	NP_733132.2	Gene:	Nf1 / 43149	FlyBaseID:	FBgn0015269	Length:	2802	Species:	Drosophila melanogaster
Sequence 2:	NP_446143.1	Gene:	Nek2 / 114482	RGDID:	619792	Length:	443	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	73/410 - (17%)
Similarity:	128/410 - (31%)	Gaps:	146/410 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1590 WSSIDMSS-TNFEEIMVKHQMHEKEEFKTLKSMNI--FYQAGTSKSGYPVFYYIARRYKIGETNG 1651
            |..:|..| |..|:.|:   :.|....:.||..||  :|.....::...:  ||...|..|   |
  Rat    36 WKELDYGSMTEVEKQML---VSEVNLLRELKHPNIVRYYDRIIDRTNTTL--YIVMEYCEG---G 92

  Fly  1652 DL---------------------LIYHVILTLKPFCH--------------SPFEVVIDFTHTCS 1681
            ||                     ::..:.|.||. ||              .|..|.:|..|...
  Rat    93 DLASVITKGTKDRQYLEEEFVLRVMTQLTLALKE-CHRRSDGGHTVLHRDLKPANVFLDSKHNVK 156

  Fly  1682 ------------DNRFRTEFLQKWFYVLP----TVAYENVHAVY-----IYNCNSWVREYTKFHD 1725
                        |..|...|:...:|:.|    .::|.....::     :|...:.:..:|.|:.
  Rat   157 LGDFGLARILNHDTSFAKTFVGTPYYMSPEQISRLSYNEKSDIWSLGCLLYELCALMPPFTAFNQ 221

  Fly  1726 RILA-----------PLK---GNRKLL----------------FLESPNKLTDFIDAEQQ----- 1755
            :.||           |.:   |...|:                .|||| .:.|.:..||:
  Rat   222 KELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEILESP-LIADLVAEEQRRNLER 285

  Fly  1756 --KLPGATLSLDEDLKVFSNALKLSHK---DTKVAIKVGPTALQITSAE--------KTKVLAHS 1807
              :..|....|.:...|.|. |||..:   |.:.|::....:|:....|        :.|:....
  Rat   286 RGRRSGEPSKLQDSSPVLSE-LKLKERQLQDRERALRAREDSLEQKERELCIRERLAEDKLARAE 349

  Fly  1808 VLLNDVYYASEIEEVCLVDDNQFTL------------------SITNESGQLSFIHNDCDNI--- 1851
            .||.:.....|...:||...::..|                  :..:|:.:.....:.|.::
  Rat   350 SLLKNYSLLKEHRLLCLAGGSELDLPSSALKKKVHFHGESKENTARSENSESQLAKSKCRDLKKR 414

  Fly  1852 -------VQAIIHIRNRWEL 1864
                   .||:..|...::|
  Rat   415 LHAAQLRAQALSDIEKNYQL 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nf1	NP_733132.2	RasGAP_Neurofibromin	1242..1575	CDD:213332
		CRAL_TRIO_2	1633..1767	CDD:404584	39/226 (17%)
		PH_NF1	1759..1868	CDD:270123	24/145 (17%)
		MOR2-PAG1_mid	<1931..>2109	CDD:372971
Nek2	NP_446143.1	STKc_Nek2	7..271	CDD:270857	46/244 (19%)
Nek2	NP_446143.1	S_TKc	8..271	CDD:214567	46/244 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1826
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900