DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nf1 and rasa2

DIOPT Version :9

Sequence 1:NP_733132.2 Gene:Nf1 / 43149 FlyBaseID:FBgn0015269 Length:2802 Species:Drosophila melanogaster
Sequence 2:NP_001090666.1 Gene:rasa2 / 100036638 XenbaseID:XB-GENE-480785 Length:834 Species:Xenopus tropicalis


Alignment Length:950 Identity:186/950 - (19%)
Similarity:335/950 - (35%) Gaps:288/950 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1040 IKTKLCQLVEVM-----MKRRD---DLAFRQEMKFRNKLVE------YLTDW---VMGTSHQIAP 1087
            ::.|:|:..:::     .|.||   .:...||..||.|:||      |..|:   :..|.|.:  
 Frog    27 LRGKICEAKQLLPYSGPNKMRDCFCTVNLDQEEIFRTKVVEKSLTPFYGEDFYFEIPRTFHNL-- 89

  Fly  1088 PSSADAAILTNTSLIFRDL---------DQACMEAVAALLRG----LPLQPEESDRGDLMDAKSA 1139
                 :..:.:.:::.|||         :..|..      .|    .||||  .|....:..|..
 Frog    90 -----SFYIYDKNVLQRDLRIGKVSIKKEDLCSS------NGKETWFPLQP--IDPNSEVQGKLH 141

  Fly  1140 LFLKYFTLFMNLLNDCIDSSEAEK-------EMNNTPLL---------------PPR---PRMAA 1179
            |.||        ||:.|..:.:.:       |....||:               |.|   .|...
 Frog   142 LELK--------LNELITENGSVQQLMVHILECEGLPLVNGQSCDPYASVSVVGPSRNEQKRTKV 198

  Fly  1180 GKLTA------------LRNATILAMSNL---------LGANIDSGLMHSIDLGYNPDLQTRAAF 1223
            .|.|:            .|:::....|:.         |...:|  |.::.:||.:..|......
 Frog   199 KKKTSNPQFNEKFYFEVTRSSSYTKKSHFQVEEEDIEKLEVRVD--LWNNGNLGQDVFLGEIRIS 261

  Fly  1224 MEVLTQ--------ILQ------QGTEFDTLA-----------ETVLADRFEQLVQLVTMISDKG 1263
            ::||..        :||      :.:::|.|.           ..:.:|.:..|..|:  :....
 Frog   262 VKVLRNDSSHRAWYLLQPKDNGSKTSKYDDLGFLRLSICYTEDHVLSSDCYSSLRSLI--LKSPE 324

  Fly  1264 ELPIAMALANVVTTSQMDELARV--LVTLFDAKHLLSPLLWNMFYREVEVSDCMQ--TLFRGNSL 1324
            ..||:.:.|.::.....|:...|  ||.|......|.|.:..:  .:::::|..:  |:||||||
 Frog   325 VRPISASPAFILGEVCRDKYDAVLPLVRLLLHHQKLVPFVAEI--AQLDLNDTQEANTIFRGNSL 387

  Fly  1325 GSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIEQHRNNLIALTQKVF 1389
            .::.:....||.|..||::.|:.::..:.| ..:.| |:||.||...::::.|:.||.....|||
 Frog   388 ATRCLDETMKIVGKHYLKVTLKNVLDEICD-SPKPC-EIDPNRLKEGDNVDNHKENLRYYVDKVF 450

  Fly  1390 DAIINSSDRFPPQLRSMCHCLYQVLSKRFPNLLQNNIGAVGTVIFLRFINPAIVSPQELGIVDKQ 1454
            ..|:.||...|..:..:...|..:..|.||........||.:.:||||...|:|||....:....
 Frog   451 FCIVKSSMSCPTVMCDIFSTLRHMAVKHFPKDPHVQYSAVSSFVFLRFFAVAVVSPHSFQLRPHH 515

  Fly  1455 VHSSAKRGLMLMSKILQNIANHVEFSK------EQHMLC--FNDFLRDHFEAGRRFFIQIASDCE 1511
            ..:...|.|.|:||.:|.:.:....:|      ::..:|  |..|..:.:....:.|::..|..|
 Frog   516 PDAQTSRILTLISKTIQTLGSVSSLTKSKPSSFKEQFMCDFFKMFEEETYTKVVKKFLEEISSTE 580

  Fly  1512 TVDQTSHSMSFISDANVLALHRLLWTHQEKIGDYLSSSRDHKAVGRRPFDKMATLLAYLGPPEHK 1576
            |.:.:..|.|.|.....:        |:..:|        ...:|::.|.|              
 Frog   581 TKEPSGVSESLILKEGEM--------HKRALG--------RTRIGKKNFKK-------------- 615

  Fly  1577 PVDSHMMFSSYARWSSIDMSSTNFEEIMVKHQMHEKEEFKTLKSMNIFYQAGTSKSGYPVFYYIA 1641
                        ||.|:    |:.|  :..|:..:||                     |||....
 Frog   616 ------------RWFSL----TSHE--LTYHKQKDKE---------------------PVFSIPI 641

  Fly  1642 RRYKIGETNGDLLIYHVILTLKPFCHSPFEVVIDFTHTCSDNRFRTEFLQKWFYVLPTVAYENVH 1706
            :.               ||.::....|.|.         .:|.|:....:|..|:...       
 Frog   642 KN---------------ILAVERLDESAFS---------KNNMFQVIHNEKPLYIQAN------- 675

  Fly  1707 AVYIYNC---NSWV-----------REYTKFHDRILAPLKGNRKLLFLESPNKLTDFIDAEQQKL 1757
                 ||   |.|:           :..:|:|..:.  |.|:  .|..::.|..|:........:
 Frog   676 -----NCIEANEWIEILSGLSRRNQKRLSKYHPSVF--LGGS--WLCCKAANDGTEGCCPCTVDV 731

  Fly  1758 PGATLSLDED--------LKVFS----NALKLSHKDTKVAIKVGPTALQITSAEKTKVLAHSVLL 1810
            | |.::||.|        .::||    ..||:......:|:..||   |...::....:..||..
 Frog   732 P-ADVALDIDGDRECERIHRLFSVNMQKLLKMEEACGTIAVYQGP---QKEHSDYNFTIEDSVTT 792

  Fly  1811 NDVYYASEIEEVCLVDDNQFTLSITNESGQLSFIHNDCDN 1850
            ..|     ::::..:.:|...|...::.|..|..:...:|
 Frog   793 FKV-----LQQIKAITENLKELHDKHKKGSTSAKYGSQEN 827

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nf1NP_733132.2 RasGAP_Neurofibromin 1242..1575 CDD:213332 80/344 (23%)
CRAL_TRIO_2 1633..1767 CDD:404584 26/147 (18%)
PH_NF1 1759..1868 CDD:270123 19/103 (18%)
MOR2-PAG1_mid <1931..>2109 CDD:372971
rasa2NP_001090666.1 C2A_RasA2_RasA3 26..146 CDD:176046 30/141 (21%)
C2B_RasA3 158..300 CDD:175977 22/143 (15%)
RasGAP_RASA2 309..580 CDD:213342 70/276 (25%)
PH_GAP1m_mammal-like 577..709 CDD:241521 37/238 (16%)
BTK 694..728 CDD:382978 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R472
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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