DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boss and grm3

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001121815.1	Gene:	grm3 / 565256	ZFINID:	ZDB-GENE-061009-13	Length:	884	Species:	Danio rerio

Alignment Length:	954	Identity:	183/954 - (19%)
Similarity:	314/954 - (32%)	Gaps:	339/954 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 RKQEEFVKILEGDVVLSVL----------------TKDP-----DSALFVINRVNQANLIMADFE 173
            ||:   :|| :||:||..|                .:|.     ::.||.|:::||...::....
Zfish    24 RKE---IKI-DGDLVLGGLFPIHEKGMGMDECGRINEDRGIQRLEAMLFAIDQINQDVALLPGVV 84

  Fly   174 IGI--------------RAISIDNASLAENLLIQEVQFLQQCTTYSMGIFVDWEL---------Y 215
            :|:              :|:....|||.:   :.:.:|:  |...|..:..|..|         :
Zfish    85 LGVHILDTCSRDTYALEQALEFVRASLTK---VDDTEFI--CPDGSYALQEDSPLAIAGVIGGSF 144

  Fly   216 KQLESVIKDLEYNIWPIP-----GTRAHLFPK-------------------VAHLLHQMPWGEKI 256
            ..:...:.:| ..::.||     .|.|.|..|                   :|.:|....|
Zfish   145 SSVSIQVANL-LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRAFNW---- 204

  Fly   257 ASVEIATETLE-MYNE-----FMEAARQEHMCL-------------------------------- 283
              ..::|...| .|.|     |.:.||..::|:
Zfish   205 --TYVSTVASEGDYGETGIEAFEQQARLRNICIATSEKVGRSSAKRSSYEAVVRQLLQKPTARVA 267

  Fly   284 -MHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDR--------TDDEFLAD-----------LP- 327
             :..:|||...:     :|:..:.|.:...|.:|.        ..:||.||           :|
Zfish   268 VLFLRSDDAREL-----IAAAARLNASFLWVASDGWGAQESIVKGNEFTADGAITLELAAHPIPD 327

  Fly   328 -NRAFVLMENEI-----------DLSTAVELDAT---------PTALDEILIGKS---------V 362
             ||.|..:..:|           :......|..|         |....|::|.||         .
Zfish   328 FNRYFQTLTPQINHRNPWFKDFWEQKFQCSLGGTSATGAGTPKPPCDQELVIDKSNFEPESKIMF 392

  Fly   363 LPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHD---------LYV----------LES------ 402
            :.:.|.:.|.::..:...|..:.::.|......|         |:|          |||
Zfish   393 VVNAVYAMAHALHRMQRTLCANTTRLCDAMRSLDGRKLYRDFLLHVNFRAPFSPAGLESQVKFDA 457

  Fly   403 ------CFNFLNF--IEDWRTSEYRQAHDTAEILSL---LLMRKLGTAMNFQMYQKKVLTLDKIT 456
                  .:|..|:  :.......|.|..:.||.|||   |:....|.              |..|
Zfish   458 YGDGVGRYNIFNYQSVPGSDKFAYVQVGEWAESLSLNEGLIGWPRGA--------------DVPT 508

  Fly   457 GE-----SRTELREIASQNFVTNVTT---YYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRYPF 513
            .:     :..|::::.:..:...:.|   .|.|..|.             |.|...|......|.
Zfish   509 SQCSDPCAPNEMKKMQAGEYCCWICTPCEPYEYLPDE-------------FTCMPCAPGQWPRPD 560

  Fly   514 L---FD-GESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLL- 573
            |   :| .|..:.|.   |.|....::.|.:|.|.||  :||||       ....|.|..:...
Zfish   561 LTGCYDLPEDYIMWE---DAWAIGPISIACVGFICTL--MVFIV-------FIRHNDTPLVKASG 613

  Fly   574 --LSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVML 636
              |..||:...|:.|.:.::...:.|.:          :|.:|...:...:...:|.||.:...:
Zfish   614 RELCYILLLGVFMSYVMTFIFIAKPSPI----------VCTLRRLGLGTSFAVCYSALLTKTNRI 668

  Fly   637 ASIGS---EGG-----FLSHVNGYIQAVICAFSVVAQVGMSVQLLVV-----MHVAS-------- 680
            |.|.|   |||     |:|..:   |..|| .|::     |||||:|     :.|..
Zfish   669 ARIFSGVKEGGAQRPRFISPSS---QVFIC-LSLI-----SVQLLLVSVWLLVEVPGTRRFTTPE 724

  Fly   681 --ETV--SCENIYYGRWLWGLLAYDFAL--LCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIW 739
              :||  .| |:.....|.. |:||..|  ||.|.|.  ...:...|:.|...|........:||
Zfish   725 KRQTVILKC-NVRDSSMLMS-LSYDVVLVVLCTVYAF--KTRKCPENFNEAKFIGFTMYTTCIIW 785

  Fly   740 VAWIAL-SLFGDEWR--DAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALPSLTSLAF 801
            :|::.: .:...::|  ...:.:.:..||:.||..:..|:..:|        :.|...::||...
Zfish   786 LAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCMFAPKVHII--------MFQPQKNVTSHRL 842

  Fly   802 AQN--------NQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEI 837
            ..|        ..|:|..||.....|.:  |:..|:...:.|.:
Zfish   843 NMNRFSVSGPATSYASHASVSAHYVPTV--CNGREIVDSTTSSL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	21/91 (23%)
grm3	NP_001121815.1	PBP1_mGluR_groupII	31..493	CDD:107370	79/478 (17%)
		ANF_receptor	61..471	CDD:279440	68/426 (16%)
		NCD3G	508..556	CDD:284890	9/60 (15%)
		7tm_3	590..828	CDD:278433	64/269 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910