Protein Alignment boss and GPRC5B

DIOPT Version :10

• Sequence 1: NP_542440.1
• Gene: boss / 43146
• FlyBaseID: FBgn0000206
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_001291700.1
• Gene: GPRC5B / 51704
• HGNCID: 13308
• Length: 534
• Species: Homo sapiens
• Alignment Length: 416
• Identity: 93/416 - (22%)
• Similarity: 166/416 - (39%)
• Gaps: 102/416 - (24%)

  Fly   510 RYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSI---- 570
            :|..|.|.:::  |.|.::         |:.|..|.:.:|:.:::.:.|..:.|....:.:
Human   175 QYVSLCDLDAI--WGIVVE---------AVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHF 228

  Fly   571 LLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVM 635
            |.||..:.:|.....:.|:            ||    .|:|:||.|:..:::...||.||.:|..
Human   229 LFLLGTLGLFGLTFAFIIQ------------ED----ETICSVRRFLWGVLFALCFSCLLSQAWR 277

  Fly   636 LASIGSEGGFLSHVNG-----YIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGRWLW 695
            :..:      :.|..|     .:...:|.  ::.||.::|:.||:..:.....:|  .|......
Human   278 VRRL------VRHGTGPAGWQLVGLALCL--MLVQVIIAVEWLVLTVLRDTRPAC--AYEPMDFV 332

  Fly   696 GLLAYDFALL-CCVG-ALIPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLF-------GDE 751
            ..|.||..|| ..:| ||.....:.:|....|..::|.:.|.::|||||:.:.||       ||.
Human   333 MALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDA 397

  Fly   752 WRDAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALPSLTSLAFAQNNQYSSEQSVYEC 816
            |.|..:.:.|.||||..::...||.....:           ||:|      |.|    ..:.::.
Human   398 WNDPTLAITLAASGWVFVIFHAIPEIHCTL-----------LPAL------QEN----TPNYFDT 441

  Fly   817 VNPAMRHCSQDEVNHQSPSEIPTLPLRGGGPRRQQFFANLRQA---NANINPQRPP----PRPQQ 874
            ..|.||     |...:...::|...:........:..|.||.|   |.::. :||.    .|| .
Human   442 SQPRMR-----ETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLG-KRPSGSLGKRP-S 499

  Fly   875 SPSRSSV------------SSLPPSP 888
            :|.||:|            .::|.:|
Human   500 APFRSNVYQPTEMAVVLNGGTIPTAP 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tmC_Boss	529..782	CDD:320170	63/270 (23%)
		TM helix 1	529..554	CDD:320170	4/24 (17%)
		TM helix 2	566..587	CDD:320170	4/24 (17%)
		TM helix 3	612..636	CDD:320170	8/23 (35%)
		TM helix 4	656..672	CDD:320170	4/15 (27%)
		TM helix 5	690..716	CDD:320170	8/27 (30%)
		TM helix 6	724..747	CDD:320170	8/22 (36%)
		TM helix 7	751..776	CDD:320170	8/24 (33%)
GPRC5B	NP_001291700.1	7tmC_RAIG2_GPRC5B	185..428	CDD:320405	65/290 (22%)
		TM helix 1	185..210	CDD:320405	6/35 (17%)
		TM helix 2	224..245	CDD:320405	4/20 (20%)
		TM helix 3	254..278	CDD:320405	8/23 (35%)
		TM helix 4	295..311	CDD:320405	4/17 (24%)
		TM helix 5	327..350	CDD:320405	6/22 (27%)
		TM helix 6	363..386	CDD:320405	8/22 (36%)
		TM helix 7	397..422	CDD:320405	8/24 (33%)