DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment boss and gprc5cl1

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_001011349.1	Gene:	gprc5cl1 / 496814	XenbaseID:	XB-GENE-990339	Length:	432	Species:	Xenopus tropicalis

Alignment Length:	434	Identity:	91/434 - (20%)
Similarity:	166/434 - (38%)	Gaps:	102/434 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   487 TSLELKTKFGQVFNCQYS-------AGDNRRYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIA 544
            |.:.|.::|.|:.:.|.:       ||.|..|.:|.|..:.  |.|.:....:.|:.:..:..|.
Frog    13 TFIWLLSRFCQLAHAQTTAVPSGCGAGINSLYYYLCDLNAA--WGIVLQAITSAGIVSTFILTIV 75

  Fly   545 TLAILVFI---VVRISLGDVFEGNPTTSILLLLSLI----LVFCSFVPYSIEYVGEQRNSHVTFE 602
            .:|...||   ..:..||        |.:..||..:    |||                ..|..:
Frog    76 LVASTPFIQNKKKKSLLG--------TQVFFLLGTLGIFGLVF----------------DMVVKK 116

  Fly   603 DAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGGFLSHVN-----GYIQAVICAFSV 662
            |..|    ||.|.|:..|::...|:.|....|.|       .:|...|     .:|..:....|:
Frog   117 DFAT----CASRRFLFGLLFAICFACLWVHGVSL-------NYLIRRNTQPSGWWIFGLAVCLSL 170

  Fly   663 VAQVGMSVQLLVVMHVASETVSCENIYYGR--WLWGLLAYDFALLCCVGALIPSIYRSQRNYRE- 724
            |..: ::.:.|::..|.:.....:....|.  ::..|:...|.:|.......|::.....::|:
Frog   171 VEAI-INTEWLIITIVKTANPPADPCLIGNADFVMALIYVMFLILAGFITAWPALCGRYGHWRKH 234

  Fly   725 GILIVIGSVLIMVIWVAWIALSLFGD-------EWRDAAIPLGLQASGWAVLVGILIP------- 775
            .|.|::...|.:.||:.||.:.::|:       .|.|..:.:.|.::|||.:...:||
Frog   235 AIFILLTLFLSISIWIVWIVMYVYGNVQVGNPLYWDDPTLAIALVSNGWAFIFFYIIPEISQLTK 299

  Fly   776 ----RTF----LIVRGIERSDIAQALPSLTSLAFAQNNQYSSEQ--SVYECVNPAMRHCSQDEVN 830
                :||    ..:||:....|.:  ...|...:.:|..:|.::  |..:.|:|...:..|...:
Frog   300 PTLEQTFEEEPYPIRGVGYETILK--EQSTQRMYVENKAFSMDEPPSAKKPVSPYSGYNGQTGKS 362

  Fly   831 HQSPSEI----PTLPLRGGGPRRQQFFANLRQANANINPQRPPP 870
            ...|:|:    .|||.|       .:...:.:|.||     |||
Frog   363 VYQPTEMALMNKTLPER-------SYDVVIPRATAN-----PPP 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	23/111 (21%)
gprc5cl1	NP_001011349.1	7tmC_RAIG3_GPRC5C	53..299	CDD:320404	56/283 (20%)
		TM helix 1	53..78	CDD:320404	4/26 (15%)
		TM helix 2	92..113	CDD:320404	8/44 (18%)
		TM helix 3	122..146	CDD:320404	7/23 (30%)
		TM helix 4	163..179	CDD:320404	2/16 (13%)
		TM helix 5	198..224	CDD:320404	5/25 (20%)
		TM helix 6	234..257	CDD:320404	7/22 (32%)
		TM helix 7	268..293	CDD:320404	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000