Protein Alignment boss and mGluR

DIOPT Version :10

• Sequence 1: NP_542440.1
• Gene: boss / 43146
• FlyBaseID: FBgn0000206
• Length: 896
• Species: Drosophila melanogaster
• Sequence 2: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Alignment Length: 897
• Identity: 148/897 - (16%)
• Similarity: 285/897 - (31%)
• Gaps: 288/897 - (32%)

  Fly    62 ISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEICLNGLQLTVNSADEG 126
            |::..:.|    |..||:|..|:       ||...:.|::            .|:.|...:.|..
  Fly   248 IAVAEKVP----SAADDKVFDSI-------ISKLQKKPNA------------RGVVLFTRAEDAR 289

  Fly   127 TVIR--------------------KQEEFVKILEG--DVVLSVLTKDPDSALF---------VIN 160
            .:::                    ||:   |:|||  |:....:|.:..|.:.         :..
  Fly   290 RILQAAKRANLSQPFHWIASDGWGKQQ---KLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTP 351

  Fly   161 RVNQANLIMADF----------EIGIRAISIDNASLAENLLIQEVQFLQQC-TTYSMGIFVDWEL 214
            ..||.|...|::          .:.::..:.::|:..:|.:  .|:...:| .:|.:...|.:|.
  Fly   352 ETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKI--GVKAKTECDDSYRLSEKVGYEQ 414

  Fly   215 YKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNEFMEAARQE 279
            ..:.:.|: |..|              ..|:.||.:.........:..|||.:
  Fly   415 ESKTQFVV-DAVY--------------AFAYALHNLHNDRCNTQSDQTTETRK------------ 452

  Fly   280 HMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAV 344
                 |.:|:...|                 ..:.|| |..:...|:.|
  Fly   453 -----HLQSESVWY-----------------RKISTD-TKSQACPDMAN---------------- 478

  Fly   345 ELDATPTALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNF 409
                        ..||....:.:|:.  |.||    |.||..|..::|:....|      :.||:
  Fly   479 ------------YDGKEFYNNYLLNV--SFID----LAGSEVKFDRQGDGLARY------DILNY 519

  Fly   410 IEDWRTSEYRQAHDTAEILSLLLMRKLGTAMNFQMYQKKVLTLDKITGESRT------ELREIAS 468
            .....:|.|:             .:.:|...|......:.:..:|.|.:..:      |:..|..
  Fly   520 QRQENSSGYQ-------------YKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKK 571

  Fly   469 QN-----FVTNVTTYYHYNRDNHTSLELKT---KFGQVFNC-----QYSAGDNRRYPFLFDGESV 520
            |.     ::.:....:.|..|..|..:...   .:....:|     ||
  Fly   572 QQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQY----------------- 619

  Fly   521 MFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFC-SFV 584
            |.|.   ..:....:..||.|:..|..::|..........|.......|..||..:::.:| :|.
  Fly   620 MKWN---SLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFA 681

  Fly   585 PYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLA----SIGSEGGF 645
            ..:...:|.                 |.::.|.:.:.:..::|.||.:...::    |.......
  Fly   682 LIAKPTIGS-----------------CVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQR 729

  Fly   646 LSHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGR-------------WLWGL 697
            |.:::...|.||....:..||     |:.::.:..|.......|..|             :|:..
  Fly   730 LKYISPQSQVVITTSLIAIQV-----LITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQ 789

  Fly   698 LAYDFAL--LCCVGAL----IPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLFGD----EW 752
            | |:..|  :|.:.|:    ||      .|:.|...|........:||:|::.: .||.    |.
  Fly   790 L-YNMILITICTIYAIKTRKIP------ENFNESKFIGFTMYTTCIIWLAFVPI-YFGTGNSYEV 846

  Fly   753 RDAAIPLGLQASGWAVLVGILIPRTFLIV----RGIERSDIAQALPSLTSLAFAQNNQYSSEQSV 813
            :...:.:.:..|....||.:..|:.:::|    :.:.:..:...:...::.|.||....||..|.
  Fly   847 QTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSR 911

  Fly   814 YECVNPAMRHCSQDEV-NHQSPSEIPTLPLRGGGPRRQQFFANLRQANANIN 864
            ...  |.....:...| .:.|.|.:||           |...:|.:|:|..|
  Fly   912 THA--PGTSALTGGAVGTNASSSTLPT-----------QNSPHLDEASAQTN 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tmC_Boss	529..782	CDD:320170	50/284 (18%)
		TM helix 1	529..554	CDD:320170	5/24 (21%)
		TM helix 2	566..587	CDD:320170	5/21 (24%)
		TM helix 3	612..636	CDD:320170	4/23 (17%)
		TM helix 4	656..672	CDD:320170	4/15 (27%)
		TM helix 5	690..716	CDD:320170	9/44 (20%)
		TM helix 6	724..747	CDD:320170	5/22 (23%)
		TM helix 7	751..776	CDD:320170	4/24 (17%)
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	68/424 (16%)
		NCD3G	556..605	CDD:462210	6/48 (13%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	49/280 (18%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	5/20 (25%)
		TM helix 3	692..716	CDD:320600	4/23 (17%)
		TM helix 4	738..758	CDD:320600	6/24 (25%)
		TM helix 5	781..807	CDD:320600	6/26 (23%)
		TM helix 6	815..838	CDD:320600	5/23 (22%)
		TM helix 7	845..870	CDD:320600	4/24 (17%)