DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boss and grm2a

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_005166174.1	Gene:	grm2a / 336153	ZFINID:	ZDB-GENE-030131-8097	Length:	894	Species:	Danio rerio

Alignment Length:	946	Identity:	176/946 - (18%)
Similarity:	308/946 - (32%)	Gaps:	352/946 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 ILEGDVVLSVL---------------------TKDPDSALFVINRVNQANLIMADFEIGIRAISI 181
            :::||:|:..|                     .:..::.|..::::||.:.|:....:|  |..:
Zfish    55 VMDGDLVIGGLFPVHHKGEGAQDCGRINTQRGIQRLEAMLLALDKINQDDQILPGVTLG--AHIL 117

  Fly   182 DNASLAENLLIQEVQFLQ-----------QCTTYSMGIFVDWEL---------YKQLESVIKDLE 226
            |..|.....|.|.::|::           .|...|..|..|..|         |..:...:.:|
Zfish   118 DTCSKDTYALEQSLEFVRASLTKVDDSEYTCPDGSYAIHDDVPLAISGVIGGSYSDVSIQVANL- 181

  Fly   227 YNIWPIP-----GTRAHLFPK-------------------VAHLLHQMPWGEKIASVEIATETLE 267
            ..::.||     .|.|.|..|                   :|.:|....|      ..::|...|
Zfish   182 LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNW------TYVSTVASE 240

  Fly   268 -MYNE-----FMEAARQEHMCL---------------------MHFKSDDNVYIMFGNK------ 299
             .|.|     |.:.||...:|:                     :..||:..|.|:|...
Zfish   241 GDYGETGIDAFQQEARALQICIATSAKVSRSMDQYSYDGVIRSLLQKSNAKVVILFTRSEDAREL 305

  Fly   300 LASHFKENGTLFSVPTD--------------------------RTDDEFLADLPN---------- 328
            |.:..:.|.:...|.:|                          .|..||.|...|
Zfish   306 LVAAKRMNVSFIWVASDGWGAQEVVVRGSESVADGAFTIELASYTIPEFAAYFTNLNPYNNTRNP 370

  Fly   329 --RAFVLMENEIDLSTAVELDATPTALDEILIGKSVL-------PSRVLSFAGSIIDLMNWLR-- 382
              |.|  .||:...|           |.:|..||..|       .|:::....::..:.|.|.
Zfish   371 WFREF--WENKFQCS-----------LHDITCGKHSLRDGKFEQESKIMFVVNAVYAMANALHHM 422

  Fly   383 -----GSLSKHCK-----RGEE-HDLYVLESCF----------NFLNF------IEDWRTSEYRQ 420
                 .:.:|.|.     .|:. :..|:|::.|          |.::|      :..:....|.:
Zfish   423 RQALCANSTKLCSAMKPVNGKRLYKDYILKTKFDAPFRPADTDNIIHFDAYGDSLGRYNIFHYHK 487

  Fly   421 AHDTAEILSLLLMRKLGTAMNFQMYQKKVLTLDK--ITGESRT----------ELREIASQN--- 470
            .:|.      .:.||:|       |..:.|||:.  |..||:.          ...||.|..
Zfish   488 ENDE------YVYRKVG-------YWAQDLTLNTTLIPWESQAVPTSQCSDPCRKNEIKSMQPGD 539

  Fly   471 ---FVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRYPF-----LFD-GESVMFWRIK 526
               ::......|.|..|..|..:  ..|||             :|.     .:| .|..:.|.
Zfish   540 VCCWICIPCQPYQYLLDEFTCAD--CSFGQ-------------WPLDNLTGCYDLPEEYIHWE-- 587

  Fly   527 MDTWVATGLTAAILGLIATLAIL-VFI------VVRISLGDVFEGNPTTSILLLLSLILVFCSFV 584
             |.|....::.|.||::.||.:: :|:      ||:.|      |...:.||||..|:..|.:|:
Zfish   588 -DAWAIGPVSIACLGMLCTLFVIGLFLKNNETPVVKAS------GRELSYILLLGVLLCYFMTFI 645

  Fly   585 PYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASI--GSEGG--- 644
                 |:            ::....:|.:|...:...:...:|.||.:...:|.|  |.:.|
Zfish   646 -----YI------------SKPSAVVCTLRRLGLGTSFAVCYSALLTKTNRIARIFNGVKDGAQR 693

  Fly   645 --FLSHVNGYIQAVICAFSVVAQVGMSVQLLVVM------------HVASE-----TVSCENIYY 690
              |:|..:   |..|||..:      |.|||||:            .|:.|     |:.|.
Zfish   694 PRFISPAS---QVAICAALI------SCQLLVVVVWLLVEAPGVRKEVSPERRDVVTLKCN---- 745

  Fly   691 GRWLWGLLAYDFALLC-----CVGALIPSIY-----RSQRNYREGILIVIGSVLIMVIWVA---- 741
                    :.|.::|.     ||..::.:.|     :...|:.|...|........:||:|
Zfish   746 --------SKDSSMLMSLTYNCVLIILCTFYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFQPI 802

  Fly   742 -WIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIV----RGIERSDIAQALPSLTSLAF 801
             ::..|.:..:.....|.:.|  ||..||..:..|:..:|:    :.:....:|....|:|:...
Zfish   803 FYVTASDYRVQTTTMCISVSL--SGSVVLGCLFAPKIHIILFQPQKNVTTLRVATTRFSVTTGPG 865

  Fly   802 AQNNQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEI 837
            :..:|.|:...|     |.:  |:..||...:.|.:
Zfish   866 SSFSQASASNIV-----PTV--CNGREVVDSTTSSL 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	19/101 (19%)
grm2a	XP_005166174.1	PBP1_mGluR_groupII	58..508	CDD:107370	83/484 (17%)
		NCD3G	520..569	CDD:311495	10/63 (16%)
		7tm_GPCRs	589..842	CDD:333717	64/298 (21%)
		TM helix 1	590..614	CDD:320095	7/23 (30%)
		TM helix 2	626..647	CDD:320095	7/25 (28%)
		TM helix 3	656..678	CDD:320095	4/21 (19%)
		TM helix 4	704..720	CDD:320095	9/21 (43%)
		TM helix 5	747..770	CDD:320095	5/22 (23%)
		TM helix 6	779..804	CDD:320095	5/24 (21%)
		TM helix 7	811..836	CDD:320095	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24060
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010