DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boss and Grm3

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	XP_008760904.1	Gene:	Grm3 / 24416	RGDID:	2744	Length:	903	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	170/951 - (17%)
Similarity:	307/951 - (32%)	Gaps:	319/951 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 EICLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEI 174
            ::.|.|| ..:|....||     ||..:|.|...:..:     ::.||.|:.:|:.|.::...::
  Rat    38 DLVLGGL-FPINEKGTGT-----EECGRINEDRGIQRL-----EAMLFAIDEINKDNYLLPGVKL 91

  Fly   175 GIRAISIDNASLAENLLIQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWP-------- 231
            |:..  :|..|.....|.|.::|::...|.     ||     :.|.:..|..|.|..
  Rat    92 GVHI--LDTCSRDTYALEQSLEFVRASLTK-----VD-----EAEYMCPDGSYAIQENIPLLIAG 144

  Fly   232 -IPGTRAHLFPKVAHLLH-----QMPWGEKIASV--------------------EIATETLEMYN 270
             |.|:.:.:..:||:||.     |:.:....|.:                    :...|.|..:|
  Rat   145 VIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFN 209

  Fly   271 -------------------EFMEAARQEHMCLMHF---------KSDDNVYIMFGNKLASHFKEN 307
                               .|.:.||..::|:...         ||.|:|           .:|
  Rat   210 WTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSV-----------IRE- 262

  Fly   308 GTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLS-TAVELDATPTALDEILIGKSVLPSRVLSFA 371
              |...|..|....|:....:|..:...|.::.| |.|..|.. .|.:.|:.|     |..:::.
  Rat   263 --LLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGW-GAQESIVKG-----SEHVAYG 319

  Fly   372 GSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLLLMRKL 436
            ...::|.:               |.:...:..|..||...:.|...:|...:.....||...|
  Rat   320 AITLELAS---------------HPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKR-- 367

  Fly   437 GTAMNFQMYQKKVLTLDKITGESRTELREIASQNFV----------------------------- 472
                |.:....|.|.:|....|..:::..:.:..:.
  Rat   368 ----NHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGK 428

  Fly   473 ---------TNVTTYYHYNRDNHTSLELKTKFG------QVFNCQYSAGDNRRYPFL-------- 514
                     .|.|..::.|:...:.::..| ||      .|||.|.:.|   :|.:|
  Rat   429 KLYKEYLLKINFTAPFNPNKGADSIVKFDT-FGDGMGRYNVFNLQQTGG---KYSYLKVGHWAET 489

  Fly   515 --FDGESVMFWR----------------------------------------------------- 524
              .|.:|:.:.|
  Rat   490 LSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQW 554

  Fly   525 ---------------IKM-DTWVATGLTAAILGLIAT-LAILVFI------VVRISLGDVFEGNP 566
                           ||. |.|....:|.|.||.:.| :.|.|||      :|:.|..::
  Rat   555 PTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGREL----- 614

  Fly   567 TTSILLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLC 631
              ..:||..:.|.:|.                ..|..|:....:||:|...:...:...:|.||.
  Rat   615 --CYILLFGVSLSYCM----------------TFFFIAKPSPVICALRRLGLGTSFAICYSALLT 661

  Fly   632 RAVMLASI--GSEGG-----FLSHVNGYIQAVICAFSVVAQVGM-SVQLLV--------VMHVAS 680
            :...:|.|  |.:.|     |:|..:   |..||...::.|:.| ||.|::        .:....
  Rat   662 KTNCIARIFDGVKNGAQRPKFISPSS---QVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKR 723

  Fly   681 ETV--SCENIYYGRWLWGLLAYDFAL--LCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIWVA 741
            |||  .| |:.....|.. |.||..|  ||.|.|.  ...:...|:.|...|........:||:|
  Rat   724 ETVILKC-NVKDSSMLIS-LTYDVVLVILCTVYAF--KTRKCPENFNEAKFIGFTMYTTCIIWLA 784

  Fly   742 WIAL-SLFGDEWR--DAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALP----SLTSL 799
            ::.: .:...::|  ...:.:.:..||:.||..:..|:..:::...:::.:...|.    |::..
  Rat   785 FLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGT 849

  Fly   800 AFAQNNQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEIPTL 840
            |...:....|:...|....|..:|.|... ...:.:.:||:
  Rat   850 ATTYSQYPPSKARPYPEAQPTPQHHSTKR-QASASTYVPTV 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	21/91 (23%)
Grm3	XP_008760904.1	PBP1_mGluR_groupII	33..494	CDD:380598	90/523 (17%)
		NCD3G	505..555	CDD:400103	0/49 (0%)
		7tmC_mGluR3	575..828	CDD:320564	64/282 (23%)
		TM helix 1	576..600	CDD:320564	9/23 (39%)
		TM helix 2	612..633	CDD:320564	5/43 (12%)
		TM helix 3	642..664	CDD:320564	5/21 (24%)
		TM helix 4	690..706	CDD:320564	5/15 (33%)
		TM helix 5	733..756	CDD:320564	8/23 (35%)
		TM helix 6	768..790	CDD:320564	4/21 (19%)
		TM helix 7	797..822	CDD:320564	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910