DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment boss and Gprc5a

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_852109.2	Gene:	Gprc5a / 232431	MGIID:	1891250	Length:	356	Species:	Mus musculus

Alignment Length:	353	Identity:	86/353 - (24%)
Similarity:	136/353 - (38%)	Gaps:	81/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 WRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYS 587
            |.|.::|..|.|..|.    :|.:..|||::.::...:..:..| ...|.||.::.||.....:.
Mouse    29 WGIALETLAAVGAVAT----VACMFALVFLICKVQDSNKRKMLP-AQFLFLLGVLGVFGLTFAFI 88

  Fly   588 IEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGGFLSHVNG- 651
            |:.            |..|..|    |.|:..:::...||.||..|..|..:         |.|
Mouse    89 IKL------------DGATGPT----RFFLFGVLFAICFSCLLAHAFNLIKL---------VRGR 128

  Fly   652 ------YIQAVICAFSVVAQVGMSVQLLVV------MHVASETVSCEN-------IYYGRWLWGL 697
                  .|.::...||:|..| ::::.||:      ::|.||..:...       :.|...|..|
Mouse   129 KPLSWLVILSLAVGFSLVQDV-IAIEYLVLTMNRTNVNVFSELPAPRRNEDFVMLLIYVLVLMVL 192

  Fly   698 LAYDFALLCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLFGD---EWRDAAIPL 759
            ..:...|:.| |:.  |.::     |.|..|...|.|.:.||||||.|.|..|   :|.|..:..
Mouse   193 TFFASFLVFC-GSF--SGWK-----RHGFHICFTSFLSIAIWVAWIVLLLIPDIDRKWDDTILST 249

  Fly   760 GLQASGWAVLVGILIPRTFLIVRGIERSDI----AQALPSLTSLAF-AQNNQYSSEQ-------- 811
            .|.|:||..|...::|....:.|....:|.    |...|.|...:: .:|..||.|:
Mouse   250 ALVANGWVFLAFYILPEFRQLPRQRSPTDYPVEDAFCKPQLMKQSYGVENRAYSQEEITQGLEMG 314

  Fly   812 -SVYECVNPAMRHCSQDEVNHQSPSEIP 838
             ::|.   |...|....  |||....||
Mouse   315 DTLYA---PYSTHFQLQ--NHQKDFSIP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	28/89 (31%)
Gprc5a	NP_852109.2	7tmC_RAIG1_4_GPRC5A_D	28..272	CDD:320406	69/281 (25%)
		TM helix 1	28..53	CDD:320406	8/27 (30%)
		TM helix 2	67..88	CDD:320406	6/21 (29%)
		TM helix 3	97..121	CDD:320406	8/27 (30%)
		TM helix 4	138..154	CDD:320406	4/16 (25%)
		TM helix 5	175..201	CDD:320406	4/25 (16%)
		TM helix 6	211..234	CDD:320406	11/22 (50%)
		TM helix 7	241..266	CDD:320406	7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..356		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870