DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment boss and F35H10.10

DIOPT Version :9

Sequence 1:	NP_542440.1	Gene:	boss / 43146	FlyBaseID:	FBgn0000206	Length:	896	Species:	Drosophila melanogaster
Sequence 2:	NP_501400.1	Gene:	F35H10.10 / 177627	WormBaseID:	WBGene00018073	Length:	1404	Species:	Caenorhabditis elegans

Alignment Length:	887	Identity:	183/887 - (20%)
Similarity:	327/887 - (36%)	Gaps:	220/887 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 IMADFEIGIRAISIDNASLAENLLIQEVQFLQQCTTYSM-------------------------- 206
            ::.|.:.|  |:.||:.|..:..:...|:...||..::.
Worm   575 LLKDLDFG--ALLIDSCSSGKQAIESVVRSETQCFRFNQAGRNITIVPKSVFGYASALHGDSQES 637

  Fly   207 --GIFVDWELYKQLESVIKD---LEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASV-EIATET 265
              |.|...:....|.||..:   |:.:...:|.:|.... .:..||::|.|....|:: |...|:
Worm   638 LKGYFSSGDTDASLVSVDSEHSALQRSFTALPSSRNQAL-ALLKLLNRMQWQFVTAALSEQDPES 701

  Fly   266 LEMYNEFMEAARQEHMCLM-----------HFKSDDNVYIMFGNK-------LASHFKENGTLFS 312
            |.::..|...|....:||.           :.:|..||.|:|...       :||  |..|...:
Worm   702 LSLFRAFERLALDRGVCLAEVLNIGGSRLDNIRSTTNVTIVFSTARDAADYLIAS--KIRGNHVN 764

  Fly   313 VPTDRTDDEFLAD------LPNRAFVLMENEI--DLSTAVELDATPTALDEILIGKSVLPSR--- 366
            |......|.:|..      .|....|...|.:  |....:| ..||..|.|:... |.:.||
Worm   765 VMMGEAHDWYLHAPNNKELFPGTVSVQPRNILYGDFREWLE-TTTPLTLPELWYW-SYIESRYGC 827

  Fly   367 VLSFAGSII--------DLMN-WLRGSLSK--HCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQ 420
            .||....:|        :|:| ...|.::|  :..||.|..|:.::|.:..|...::....|:
Worm   828 ALSQKSKVIYGKMCTGDELLNIESLGRMTKAGYLSRGVERFLFAMDSVYKSLCPAQNGLCLEF-- 890

  Fly   421 AHDTAEILSLLLMRKLGTAMNFQMYQKKVLT-LDKITGESRTELRE-------------IASQNF 471
                                 ::..::::|| |.|.:.|...|:.|             ||:...
Worm   891 ---------------------YEQGRRQILTQLKKTSTEDDVEIYEFLPDINNHFTYHLIANWTL 934

  Fly   472 VTNVTTYYHYNRDNHTSLELKTK-----------FGQ------VFNCQYSAGDNR---------- 509
            .|.:.....|...|....|.|.:           |.|      ||......|.::
Worm   935 TTGLRMTNQYRNGNGVPTESKCQPPMCKCFLDGDFFQRPLDSFVFRPDEPEGSDQSSYIKRQPAF 999

  Fly   510 -----RYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTS 569
                 .|..:|:..:...||.....:|...|...:  ::..:|:||.::|::.| .|.:||.:..
Worm  1000 GSEKIEYQSVFEHITTGHWRDHPHNYVLLALITVL--VVVAIAVLVLVLVKLYL-RVVKGNQSLG 1061

  Fly   570 ILLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAV 634
            |.||:.:|:::                |...|......:::|.:||.:..|.|...|.:::.:|.
Worm  1062 ISLLIGIIILY----------------STAFFFVFDPTDSVCRLRVILHGLGYTICFGVMIAKAT 1110

  Fly   635 MLASIGSEG-GFLSHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGRWLWGLL 698
            .|.:..:.| |...|::.:...::..|.|..|:.:|:...:...:::..|...|:.  |.:..:.
Worm  1111 QLRNAETLGFGTAIHISFWNYWLLLFFIVGVQIALSISWFLEPFMSTIGVIDTNVQ--RMMCTMG 1173

  Fly   699 AYDFA-------LLCCVGALIPSIYRS-QRNYREGILIVIGSVLIMVIWVAWIALSLFGD-EWRD 754
            ..:|.       :|..:...|..:.|: :|||:|...::..:||....|||||.|.|..| |:||
Worm  1174 KVEFVVSNFYVMILIFMALFISMLNRNIKRNYKETKWLLYSTVLCFFTWVAWITLYLVLDHEFRD 1238

  Fly   755 AAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIA---QALPSLTSLAFAQNNQYSSEQSVYEC 816
            ..|.:.|.|.. .:|:|.|......|:...|...:|   ...|:.|.| |.:::...|:::
Worm  1239 TVIVVELVACA-TILLGFLFGPKIYILLSYEPVVVAFKRDPFPNHTDL-FEKDDDLPSQRA---- 1297

  Fly   817 VNPAMRHCSQDE-----VNHQSPSEIPT-----LPLRGGGPRRQQFF-------ANLRQANA--- 861
            |:||....|...     .::.|.|:.|.     |||......:...|       ..:|::|:
Worm  1298 VSPASSTSSSSNRSSSGSSYTSSSKRPVNAVGPLPLNKNVEDQSPIFHTVMRKKTKVRRSNSEHD 1362

  Fly   862 ---NIN-PQ------RPPPRPQQSPSRSSVSSLPPSPDHNKI 893
               |:. |.      |.|....:...|.::|  ||..|:|.|
Worm  1363 TIMNVGIPMTSVPIIRSPSARDEKVHRVAIS--PPIRDYNSI 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
boss	NP_542440.1	7tm_3	<692..779	CDD:278433	28/95 (29%)
F35H10.10	NP_501400.1	PBP1_GPCR_family_C-like	57..354	CDD:380573
		PBP1_GPCR_family_C-like	532..809	CDD:380573	46/239 (19%)
		7tm_classC_mGluR-like	<1072..1266	CDD:320091	48/212 (23%)
		TM helix 3	1088..1112	CDD:320091	6/23 (26%)
		TM helix 4	1131..1150	CDD:320091	4/18 (22%)
		TM helix 5	1173..1199	CDD:320091	3/25 (12%)
		TM helix 6	1207..1230	CDD:320091	9/22 (41%)
		TM helix 7	1237..1260	CDD:320091	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960