DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and SLC5A1

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_000334.1	Gene:	SLC5A1 / 6523	HGNCID:	11036	Length:	664	Species:	Homo sapiens

Alignment Length:	614	Identity:	145/614 - (23%)
Similarity:	253/614 - (41%)	Gaps:	160/614 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SSTPTTSTTFAYTPTPTPTQSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGF 122
            |||.:..||....|           :|..|...:..|:|        :..:.|:.::||    |.
Human     3 SSTWSPKTTAVTRP-----------VETHELIRNAADIS--------IIVIYFVVVMAV----GL 44

  Fly   123 YFGFIEKKQKKQKLAGKDGGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFVS-----GI 182
            :..|...:       |..||               :.:.||.|..:|:..||.||.:.     |:
Human    45 WAMFSTNR-------GTVGG---------------FFLAGRSMVWWPIGASLFASNIGSGHFVGL 87

  Fly   183 SLLGTSTEIYVYGTQY-AFILVTLAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGS 245
            :..|.::.|.:.|.:: |.:||.:     :.| :|:|::....:.:..||..:|| .:|::::.|
Human    88 AGTGAASGIAIGGFEWNALVLVVV-----LGW-LFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLS 146

  Fly   246 CLFVVMNILWQ-PICIYVPALTLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVM 309
            .|.:::.|..: ...|:..|:.:|...|:::...:.:...|..|||..||:..|::||.:|..:|
Human   147 LLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIM 211

  Fly   310 IGSMLIVIIKGTLDLGGLSVVLDHNRQYDRLVGPDMTFDP---------TARMGVFALF------ 359
            :...||:......::||....::   :|.:.: |.:..|.         |.|...|.:|
Human   212 LVGSLILTGFAFHEVGGYDAFME---KYMKAI-PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTG 272

  Fly   360 --------VGGALFKLQANGINQAIVQRYLTLPNNKDVKKALVLSLIGF-----MFVMLMCVYIG 411
                    .|.::..|.....:|.||||.|:..|...||...:  |.|:     ||:|:|...|.
Human   273 DLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCI--LCGYLKLMPMFIMVMPGMIS 335

  Fly   412 LLAFAEFYHCDPITTGLARAKDQVIPLYVVK---------NVGH-------IP-GLVGLFVAGVF 459
            .:.:.|...|             |:|....|         |:.:       :| ||.||.::.:.
Human   336 RILYTEKIAC-------------VVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVML 387

  Fly   460 SAALSSLSTALNSLSGVILTDFVEPFRKKPLTERQTAYLLRG---VVISFGLISMASVPIVQ--R 519
            ::.:|||::..||.|.:...|.....||: .:|::  .::.|   :::..| ||:|.|||||  :
Human   388 ASLMSSLTSIFNSASTLFTMDIYAKVRKR-ASEKE--LMIAGRLFILVLIG-ISIAWVPIVQSAQ 448

  Fly   520 LGLVMQLSSTVAAIT--CGPLLGAFSVGMLLPFVKTES-----------LLTGISCASSFTAYIV 571
            .|   ||...:.:||  .||.:.|  |.:|..|.|..:           ||.|||...:..||
Human   449 SG---QLFDYIQSITSYLGPPIAA--VFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAY-- 506

  Fly   572 VRAQIAIFTGSLTFPAK-PVSIQDCDYTF 599
                   .|||...|:. |..|....|.:
Human   507 -------GTGSCMEPSNCPTIICGVHYLY 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	135/567 (24%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	137/579 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740