DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42235 and Slc5a4a

DIOPT Version :9

Sequence 1:	NP_651446.2	Gene:	CG42235 / 43136	FlyBaseID:	FBgn0250757	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_573447.2	Gene:	Slc5a4a / 64452	MGIID:	1927848	Length:	656	Species:	Mus musculus

Alignment Length:	560	Identity:	129/560 - (23%)
Similarity:	230/560 - (41%)	Gaps:	96/560 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TQSASPSLEDGEEKLSVKDLSQALQHFGIVDYLVFIAMLAVCAVIGFYFGFIEKKQKKQKLAGKD 140
            |.|.|.|....|......:::.|.....||.|.|.:..:.|.|::         |..:..:.|
Mouse     4 TASVSTSTASSELSSLSNNINNAADISVIVIYFVVVMAVGVWAML---------KTNRSTVGG-- 57

  Fly   141 GGGAAGVEERRGSEALDYLVGGRQMKVFPVALSLVASFV-SG--ISLLGTSTEIYVYGTQYAFIL 202
                             :.:.||.|..:|:..||.||.: ||  :.|.||.....:..|  ||..
Mouse    58 -----------------FFLAGRSMTWWPMGASLFASNIGSGHFVGLAGTGAASGIAVT--AFES 103

  Fly   203 VTLAISGAISWYIFLPVFCNLQLTSTYEYFERRF-DRRVRIFGSCLFV-VMNILWQPICIYVPAL 265
            .:.|:...:.| ||:|::....:.:..||.::|| .:|::|:.|.||: :..||.....|:..|:
Mouse   104 HSFALLLVLGW-IFVPIYIKAGVMTMPEYLKKRFGGKRLQIYLSILFLFICVILTISADIFSGAI 167

  Fly   266 TLNQVSGISVSKIVPVTSFICILYTSVGGIKGVVWTDVIQGTVMIGSMLIVIIKGTLDLGGLSVV 330
            .:....|:::...:.:...|..::|..||:..|::||.:|..:|:....|:::...:::||....
Mouse   168 FIKLALGLNLYLAILILLAITAIFTITGGLASVIYTDTVQAVIMLVGSFILMVFAFVEVGGYESF 232

  Fly   331 LDH--NRQYDRLVGPDMTFDP---TARMGVFALF----VG-----GALFKLQANG-----INQAI 376
            .:.  |.....:.|.::|.:.   |.:...|.:|    .|     |..|.:....     |||.|
Mouse   233 TEKFMNAIPSVVEGDNLTINSRCYTPQPDSFHIFRDPVTGDIPWPGTAFGMPITALWYWCINQVI 297

  Fly   377 VQRYLTLPNNKDVKKALVLSLIGF-----MFVMLMCVYIGLLAFAEFYHCDPITTGLARAKDQVI 436
            |||.|...|...||.|.:  |.|:     :|.|:|...|..:.:.:...|             |:
Mouse   298 VQRCLCGKNLSHVKAACI--LCGYLKLLPLFFMVMPGMISRILYTDMVAC-------------VV 347

  Fly   437 PLYVVKNVG----------------HIP-GLVGLFVAGVFSAALSSLSTALNSLSGVILTDFVEP 484
            |...||:.|                .:| ||.||.::.:.::.:|||::..||.|.:...|....
Mouse   348 PSECVKHCGVDVGCTNYAYPMLVLKLMPMGLRGLMLSVMLASLMSSLTSVFNSASTLFTIDLYTK 412

  Fly   485 FRKKPLTERQTAYLLRGVVISFGLISMASVPIVQ--RLGLVMQLSSTVAAITCGPLLGAFSVGML 547
            .||| .:||:.....|..|....:.|:..||||:  :.|.::..:..:::....|:...|.|.:.
Mouse   413 IRKK-ASERELLIAGRLFVSVLIVTSILWVPIVEVSQGGQLVHYTEAISSYLGPPIAAVFLVAVF 476

  Fly   548 LPFVKTESLLTGISCASSFTAYIVVRAQIAIFTGSLTFPA 587
            ......:....|: ........|.:.|:.:..|||...|:
Mouse   477 CKRANEQGAFWGL-MVGLVMGLIRMIAEFSYGTGSCLAPS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42235	NP_651446.2	SLC5sbd_NIS-SMVT	105..646	CDD:271383	122/531 (23%)
Slc5a4a	NP_573447.2	SLC5-6-like_sbd	27..656	CDD:294310	123/537 (23%)
Slc5a4a	NP_573447.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..593
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740